Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Characterization and Controlled Release of Solid Dispersed Sibutramine

시부트라민 고체 분산체의 특성화 및 조절된 방출거동

  • Park, Jung-Soo (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Ku, Jeong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Lee, Jun-Hee (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Yun-Tae (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Park, Jong-Hak (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Ahn, Sik-Il (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Mo, Jong-Hyun (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Lee, Hai-Bang (Nanobiomaterials Lab, Korea Research Institute of Chenmical Technology) ;
  • Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
  • 박정수 (BK-21 고분자 BIN 융합연구팀) ;
  • 구정 (BK-21 고분자 BIN 융합연구팀) ;
  • 이준희 (BK-21 고분자 BIN 융합연구팀) ;
  • 김윤태 (BK-21 고분자 BIN 융합연구팀) ;
  • 박종학 (BK-21 고분자 BIN 융합연구팀) ;
  • 안식일 (BK-21 고분자 BIN 융합연구팀) ;
  • 모종현 (BK-21 고분자 BIN 융합연구팀) ;
  • 이해방 (한국화학연구원 생체분자전달제어팀) ;
  • 강길선 (BK-21 고분자 BIN 융합연구팀)
  • Published : 2008.04.21
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Abstract

Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.

Keywords

References

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