Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

BISPHOSPHONATE(ZOLEDRONIC ACID) RELATED OSTEOMYELITIS ON MANDIBLE-A CASE REPORT

Bisphosphonate(Zoledronic acid)와 연관된 하악골의 골수염-증례보고

  • Lee, Su-Youn (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Choi, So-Young (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Jin-Wook (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kwon, Tae-Geon (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Jang, Hyung-Jung (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Chin-Soo (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Lee, Sang-Han (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University)
  • 이수연 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 최소영 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 김진욱 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 권대근 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 장현중 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 김진수 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 이상한 (경북대학교 치과대학 구강악안면외과학교실)
  • Published : 2008.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

Bisphosphonate are a class of drugs with a chemical structure which inhibit bone resorption, actually used for metastatic bone disease, osteoporosis, Paget's disease and multiple myeloma. Significant complication associated with their use is reported recently : mandibular and maxillary osteomyelitis or osteonecrosis. So we here report our case about the patient who was diagnosed of prostate cancer in 2004 April and treated with bisphosphonate(Zoledronic acid-$Zometa^{(R)}$, Novartis Co.) intravenously every 3 to 4weeks at a dose of 4mg to prevent bone metastasis, and also, the patient who came to the hospital due to the bony exposure of mandible and pain in 2006 November and was diagnosed osteomyelitis of mandible as a result of biopsy, bone scan, PET CT examination.

Keywords

References

  1. Rossi R, Dorto O, Agazzi A et al : Bisphosphonate-vascular osteonecrosis of the jaws:Medical or surgical approach? J Cranio-Maxillofac Surg 34 : 34, 2006
  2. Ruggiero SL, Fantasia J, Carlson E : Bisphosphonaterelated osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 : 433, 2006 https://doi.org/10.1016/j.tripleo.2006.06.004
  3. Olson KB, Hellie CM, Pienta KJ : Osteonecrosis of jaw in patient with hormone-refractory prostate cancer treated with zoledronic acid. Urology 66 : 658, 2005
  4. Dannemann C, Gratz KW, Riener MO et al : Jaw osteonecrosis related to bisphosphonate therapy: A severe secondary disorder. J Bone 40 : 828, 2007 https://doi.org/10.1016/j.bone.2006.11.023
  5. Marx RE, Sawatari Y, Fortin M et al : Bisphosphonate-Induced Exposed Bone (Osteonecrosis/Osteopetrosis) of the Jaws: Risk Factors, Recognition, Prevention, and Treatment. J Oral and Maxillofac Surg 63 : 1567, 2005 https://doi.org/10.1016/j.joms.2005.07.010
  6. Mehrotra B, Fantasia J, Nissel HS et al : Osteonecrosis of the maxilla: an unusual complication of prolonged bisphosphonate therapy. A case report. Proc Am Soc Clin Oncol 22 : 75, 2003
  7. Rosenberg TJ, Ruggiero SL : Osteonecrosis of the jaws associated with the use of bisphosphonates. J Oral and Maxillofac Surg 61 : 60, 2003 https://doi.org/10.1016/S0278-2391(03)00566-4
  8. Ruggiero SL, Mehrotra B, Rosenberg TJ et al : Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral and Maxillofac Surg 62 : 527, 2004 https://doi.org/10.1016/j.joms.2004.02.004
  9. American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws. J Oral and Maxillofac Surg 65 : 369, 2007 https://doi.org/10.1016/j.joms.2006.11.003
  10. Senel FC, Tekin US, Durmus A et al : Severe Osteomyelitis of the Mandible Associated With the Use of Non-Nitrogen-Containing Bisphosphonate (Disodium Clodronate): Report of a Case. J Oral and Maxillofac Surg 65 : 562, 2007 https://doi.org/10.1016/j.joms.2006.10.043