The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effect of Whitmania pigra whitman on the Allergic Inflammatory Response

수질(水蛭)이 비만세포의 알러지 염증 반응에 미치는 영향

  • Lee, Ju-Yong (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Eun-Kyoung (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Oh, Hyun-A (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hyun-Sam (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Sohn, Young-Joo (College of Oriental Medicine, Sangji University) ;
  • Jung, Hyuk-Sang (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Yoon-Bum (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Park, Seong-Kyu (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Sohn, Nak-Won (Graduate School of East-West Medicine, Kyung Hee University)
  • 이주용 (경희대학교 한의과대학 한의학연구소) ;
  • 김은경 (경희대학교 한의과대학 한의학연구소) ;
  • 오현아 (경희대학교 한의과대학 한의학연구소) ;
  • 이현삼 (경희대학교 한의과대학 한의학연구소) ;
  • 손영주 (상지대학교 한의과대학) ;
  • 정혁상 (경희대학교 한의과대학 한의학연구소) ;
  • 김윤범 (경희대학교 한의과대학 한의학연구소) ;
  • 박성규 (경희대학교 한의과대학 한의학연구소) ;
  • 손낙원 (경희대학교 동서의학대학원)
  • Published : 2008.06.30
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Abstract

Objectives: Whitmania pigra whitman (WP) has been used in herbal medicine to treat various conditions, such as eczema, skin burns and frostbites in herbal medicine. The purpose of this study is was to investigate the effect of WP on anti-allergy mechanism. Methods: To clarify the mechanism, the effect of WP on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, $TNF-{\alpha}$) released from mast cells were observed. Results: The results were 1. the pretreatment with WP significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC 2. WP did not inhibit the anti-DNP IgE-induced increment of vascular permeability of rat cutaneous tissue 3. WP significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and $TNF-{\alpha}$ in HMC-1 cells. Conclusions: The present study providesevidence that WP acid inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of action. Furthermore, in vivo and in vitro anti-allergic effect of WP suggests a possible therapeutic application of this agent in inflammatory allergic diseases.

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