한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제21권1호
  • /
  • Pages.64-70
  • /
  • 2008
  • /
  • 1225-4339(pISSN)
  • /
  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
권호 표지

고지방 식이와 병행 섭취한 천마 분말이 흰쥐의 혈청 및 간 조직 지질 함량에 미치는 영향

Effect of Gastrodiae rhizoma Powder on Serum and Liver Lipid Levels of Rats with High Fat Diet

  • 조화은 (원광대학교 한의학전문대학원 한방건강증진연구개발팀) ;
  • 최윤희 (원광대학교 한의학전문대학원 한방건강증진연구개발팀) ;
  • 박성혜 (명지대학교 산업대학원 식품양생학과) ;
  • 박용수 (무주군약초영농조합법인) ;
  • 안병용 (전북대학교 환경자원학부)
  • Cho, Hwa-Eun (Dept. of Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Yun-Hee (Dept. of Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Hye (Dept. of School of Industrial Technology, Myungji University) ;
  • Park, Yong-Soo (Dept. of MJ Health Foods Association) ;
  • Ahn, Byung-Yong (School of Environmental and Resource, Chonbuk National University)
  • 발행 : 2008.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was performed to study the effects of Gastrodiae rhizoma on lipid concentration of serum and liver in rats fed high fat diet. Male Sprague-Dawley rat were randomly assigned to 5 groups such as basal diet only(BDG), high fat diet(HFG) and high fat diet with 5% processed Gastrodiae rhizoma(GRL), high fat diet with 10% processed Gastrodiae rhizoma(GRM), high fat diet with 15% processed Gastrodiae rhizoma(GRH) supply each of the experimental diets for 6 weeks. Food intake was significantly decreased by both high fat intake and high fat with Gastrodiae rhizoma intake compared with basal diet intake but weight gain was not significantly different from each groups. Liver weights were significantly lowered by Gastrodiae rhizoma intake compared with high fat intake. In the serum, total cholesterol was not significantly different with each groups, but triglyceride level was significantly lowered by Gastrodiae rhizoma intake as compared with control. In the liver, lipid levels inceased with the Gastrodiae rhizoma intake, but total cholesterol and triglyceride levels were not significantly different with control. These results showed that dietary Gastrodiae rhizoma as supplementary food may decrease triglyceride in the serum.

키워드

참고문헌

  1. Korea National Statistical Office. Statistics of Death Cause. Seoul. 2004
  2. Connor, WE, Stone, DB and Hodges, RE. The interrelated effects of dietary cholesterol and fat upon human serum lipid levels. J. of Clin. Invest. 43:1691-1696. 1994
  3. Lee, YC, Shin, HA, Lee, KY, Park, YH and Rhee, JS. A study in concentration of serum lipids and food & daily habit of healthy Korean adults-Emphasis in serum triglyceride. Kor. J. of Lipidology. 2:41-51. 1992
  4. Soen, YS. A study of hyperlipidemia in Koreans(I). J. of Kor. Med. Assoc. 18:345-354. 1975
  5. Yang, JM, Lee, JI, Kim, SJ, Song, BS, Kee, DH, Park, SC and Soen, IS. A study of pattern by the type of hyperlipidemia on the all disease in Koreans. J. of Kor. Med. Assoc. 7:151-159. 1980
  6. Grundy, SM and Denky, MA. Dietary influences on serum lipids and lipoproteins. J. Lipid Res. 31:1149-1172. 1990
  7. Ebenbichler, CF, Kichmair, R, Eagger, C and Patch, JR. Postprandial state and atherosclerosis. Cureent Opinion in Lipidology. 6:286-290. 1995 https://doi.org/10.1097/00041433-199510000-00008
  8. Goldberg, IJ. Lipoprotein lipase and lipolysis, central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37:693-707. 1996
  9. Lee, BY, Yang, YM and Han, CK. Analysis of the aroma pattern of Gastrodia rhizoma by the drying condition. J. Kor. Soc. Food Sci. Nutr. 34: 13-17. 2002
  10. 彭銘泉. 中國藥膳大典, pp 133-141. 靑島出版社, 中國. 2000
  11. Taguchi, H, Yosioka, I, Yamasaki, K and Kim, IL. Studies on the constituents of Gastrodia elata Blume. Chem. Pharm. Bull. 29, 55-62. 1996
  12. Park, PS, Sung, NJ and Park, MY. Effects of Gastrodia rhizoma on lipid components of liver, brain and kidney in hypercholesterolemic rats. Theses collection, Sangju Nat'l University Sangju-City. Korea. 6:385-392. 1999
  13. Paik, YS, Song, JK, Yoon, CH, Chung, KC and Yun, HS. Anti-platelet and anti-thrombotic effects of Gatrodia elata. Kor. J. Pharmacogn. 26:385-389. 1995
  14. 項平. 中國食療方全錄, pp 90-94. 人民衛生出版社, 中國. 1997
  15. Friedwald, WT, Levy, RI and Fredrickson, DS. Estimation of the LDL-cholesterol plasma without use of the preparation ultracentrifuge. Clin. Chem. 18:499-502. 1972
  16. Haglund, O, Loustarinen, R, Wallin R, Wibell, I and Saldeen, T. The effect of fish oil on triglyceride, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin. Eur. J. Nutr. 121:165-172. 1991 https://doi.org/10.1093/jn/121.2.165
  17. Folch, J, Lees, M and Sloane-Stanley, GHS. Simple method for the isolation of total lipids from animal tissues. J. Biol. Chem. 22:497-509. 1983
  18. Oh, KY. Histopathological Technics and Staining Method. p159. 1987
  19. Melanson, KJ, Westerterp-Plantenga, MS, Saris, WHM and Campgield, LA. Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Regul. Integr. Comp. Physiol. 46:337-345. 1999
  20. Westerterp-Plantenga, MS, Kovacs, EMR and Melanson, KJ. Habitual meal frequency and energy intake regulation in partially temporally isolated men. Int. J. Obes. Relat. Metab. Disord. 26:102-110. 2002 https://doi.org/10.1038/sj.ijo.0801855
  21. Kim, MH, Jang, SY and Lee, YS. Effect of dietary fat and genistein on lipid metabolism and antiosidant activity in hyperlipidemic male fats induced high fat diet. Kor. J. Nutr. 39:100-108. 2006
  22. Koh, JB and Choi, MA. Effect of Cordyceps militaris on lipid metabolism in rats fed cholesterol diet. Kor. J. Nutr. 34:265-270. 2001
  23. Park, PS, Sung, NJ and Park, MY. Ettects of Dioscorea batatas and Gastrodiae rhizoma on lipid compositional changes of liver, brain and kidney in rats. J. East Asian Soc. Dietary Life. 9:188-194. 1999
  24. Oh, JD, Yoon, CG and Yu, TS. Effects of dietary Monascus koji on the liver damage induced by bromobenzene in rats. J. Kor. Soc. Food Sci. Nutr. 33:965-972. 2004 https://doi.org/10.3746/jkfn.2004.33.6.965
  25. Shin, CS, Park, CK, Lee, JW, Lee, JG, Jang, CK and Kim, YK. Analysis of the components with freeze drying and steam drying of Gastrodia elata Blume. J. Kor. Soc. Food Sci. Nutr. 28:1058-1063. 1999
  26. Hong, HD, Kim, YC, Keum, IK, Kim, SS, Kim, KI and Han, CK. Effect of Gastrodiae rhizoma fractions on serum lipid concentrations in rats fed with high fat diet. J. Kor. Soc. Food Sci. Nutr. 48:370-374. 2005