Mycobiology

The Korean Society of Mycology (한국균학회)
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Antimicrobial Activity of Some Schiff Bases Derived from Benzoin, Salicylaldehyde, Aminophenol and 2,4 Dinitrophenyl Hydrazine

  • Jesmin, Mele (Department of Applied Chemistry and Chemical Technology, Rajshahi University) ;
  • Ali, M. Mohsin (Department of Applied Chemistry and Chemical Technology, Rajshahi University) ;
  • Salahuddin, M.S. (Department of Biochemistry and Molecular Biology, Rajshahi University) ;
  • Habib, M. Rowshanul (Department of Biochemistry and Molecular Biology, Rajshahi University) ;
  • Khanam, Jahan Ara (Department of Biochemistry and Molecular Biology, Rajshahi University)
  • Published : 2008.03.31
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Abstract

The antibacterial and antifungal activities of three schiff bases were evaluated against some pathogenic bacteria and fungi. Parallel experiments were also carried out with standard drugs (Kanamycin for bacteria and Nystatin for fungi). Two compounds [N-(1-phenyl-2-hydroxy-2phenylethylidine)-2',4' dinitrophenyl hydrazine, abbreviated as PDH and N-(2-hydroxy benzylidine)-2'-hydroxy imine, abbreviated as HHP] showed significant antimicrobial activities. The rest one [N-(l-phenyl 2-hydroxy-2 phenyl ethylidine) 2'-hydroxy phenyl imine, abbreviated as PHP] showed moderate activity. All these three compounds were found to possess pronounced cytotoxic effect. These compounds can be considered as potent antimicrobial agents.

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References

  1. Atta-ur-Rahman, M. I. C. and Thomson, W. J. 1999. Manual of Bioassay Techniques for Natural Product Research, pp. 12-22. Howard Academic Press. Amsterdam
  2. Bauer, A. W., Kirby, W. M., Sherris, J. C. and Truck, M. 1966. Antibiotic susceptibility testing by a Standardized single disc method. Am. J. Chin. Pathol. 44:493-496
  3. Collins, F. M., Klayman, D. L. and Morrision, N. E. 1982. Correlations between structure and antimycobacterial activity in a series of 2-acetylpyridine thiosemicarbazones. J. Gen. Microbiol. 128:1349-1356
  4. Chen, H. and Rhodes, J. 1996. Schiff base forming drugs mechanisms of immune potentiation and therapeutic potential. J. Mol. Med. 74:497-504 https://doi.org/10.1007/BF00204975
  5. Das, P. K., Bhattacharya, S. K. and Sen, P. 1995, Pharmacology, B. T. Churchill Livingstone Pvt Ltd., New Delhi, India
  6. Dobek, A. S., Klayman, D. L., Dickson E. J. Scovill, J. P. and Tramont, E. C. 1980. Inhibition of clinically significant bacteria organisms in vitro by 2-acetylpyridine thiosemicarbazones. Antimicrob. Agents Chemother. 18:27-56 https://doi.org/10.1128/AAC.18.1.27
  7. Jawetz, E., Melnick, J. L. and Adelberg, E. A. 1980. Review of Medical Microbiology. Lange. 14th ed., Med. Pub., California, pp. 123-124
  8. Khanam, J. A., Akhtaruzzaman, M., Masud Rana, A. Y. K. M. and Shajahan, M. 2002. In vitro antibacterial activity of 2, 2 diamino-1-azavinyl amino amide, J. Med. Sci. 2:198-201 https://doi.org/10.3923/jms.2002.198.201
  9. Meye, B. N., Ferrigini, N. R., Putnum, J. E., Jacobson, L. B., Nicholas, D. E. and Mclaughlin, J. L. 1982. Brine shrimp: A convenient general bioassay for active constituents, Planta Medica 45:31-34 https://doi.org/10.1055/s-2007-971236
  10. Pandeya, S. N., Sriram, D., Nath, G. and Declercq, E. 1999. Synthesis, antibacterial, antifungal and anti HIV activities of schiff and mannich bases derived from isatin derivatives and N-[4-(4' chlorophenyl) thiazol-2-yl] thiosemicarbazide, Eur. J. Pharm. Sciences 9:25-31 https://doi.org/10.1016/S0928-0987(99)00038-X
  11. Rois, J. J., Reico, M. C. and Villar, A. 1988. Antimicrobial screening of natural products. J. Enthopharmocol. 23:127-149 https://doi.org/10.1016/0378-8741(88)90001-3

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