Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

EFFECT OF PLATELET-RICH PLASMA ON AUTOGENOUS BONE GRAFT FOR BONE FORMATION IN RABBIT

가토 하악골 결손부의 자가골 이식시 혈소판 풍부혈장이 골형성 촉진에 미치는 영향에 관한 연구

  • Jeon, Min-Su (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Kim, Bo-Gyun (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Song, Jun-Ho (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Yeon, Byong-Moo (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Lee, Young-Woo (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Noh, Kyung-Lok (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Kim, Da-Young (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Pang, Ean-O (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Kim, Jun-Hyun (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Nam, Jeong-Hun (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Gang, Tae-In (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Lim, Sung-Chul (Department of Pathology, College of Medicine, Chosun University) ;
  • Park, Young-Ju (Department of Oral and Maxillofacial surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University)
  • 전민수 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 김보균 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 송준호 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 연병무 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 이영우 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 노경록 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 김다영 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 방은오 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 김주현 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 남정훈 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 강태인 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 임성철 (조선대학교 의과대학 병리학교실) ;
  • 박영주 (한림대학교 의과대학 구강악안면외과학교실)
  • Published : 2008.03.31
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Abstract

Purpose : Recently, various materials were developed for enhancing bone formation capacity. Platelet rich plasma(PRP) is an autologous source with several growth factors and obtained by sequestering and concentrating platelets by gradient density centrifugation. This study was to evaluate the effect of PRP on healing of grafted bone. Materials and methods : Two blood samples were obtained and analysed for measuring platelet counts of normal blood and PRP. In experimental group, two defects of mandibular bone, 10mm in diameter and 4.0mm deep, were created in the mandible and immediately grafted with autogenous bone chips mixed with PRP. In control group, same bone defects were prepared and grafted with autogenous bone chips. Gelform was used for carrier of PRP. 2 weeks, 4 weeks, 8 weeks later, each group was evaluated with histologi-cal and histomorphometric analyses. Results : According to histological observation, experimental group was showed more anastomosing newly-formed woven bone having osteoblastic activation than control group. According to histomorphometric analysis, there were 9.11% more newly-formed bone volume in experimental group than control group at 2 weeks, 7.91% more at 4 weeks, 20.08% more at 8 weeks. Conclusion: Our results demonstrated PRP in autogenous bone graft could enhance the bone formation.

Keywords

References

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