대한한의학회지 (The Journal of Korean Medicine)
- 제29권1호
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- Pages.67-84
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- 2008
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
자심활혈탕(滋腎活血湯)이 전신성홍반성낭창(全身性紅斑性狼蒼) 동물모델에 미치는 영향(影響)
Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus
- Choi, Hoon-Seob (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Cho, Chung-Sik
(Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Kim, Cheol-Jung
(Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.03.31
초록
Objective : The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus. Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks. Results : The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated