Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Effects of Gamdutang on Protection Against Accumulation of Cadmium in Rats

  • Lee, In-Sook (Department of Public Health, Graduate School of Chungnam National University) ;
  • Cho, Young-Chae (Department of Preventive Medicine and Public Health, College of Medicine, Chungnam National University, and Research Institute for Medical Sciences)
  • Published : 2008.10.31
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Abstract

These experiments were conducted to determine the effects of Gamdutang on the accumulation of cadmium in the body of groups of rats that received an 8-week administration of 1.7, 3.4 and $6.8{\mu}g$/g/day of cadmium, respectively, while the other groups of rats received an 8-week administration of a mixture of cadmium by concentration and Gamdutang. A comparative analysis of these groups was conducted in respect of weight, accumulated cadmium in blood and diverse organs and pathological findings from the kidneys. As for the cadmium accumulation in blood, livers, kidneys, and testis, with the lengthening of the experiment period, the cadmium and Gamdutang mixture-administered groups tended to have reduced accumulation levels compared with the groups exclusively administered cadmium. Histopathological observation of the kidneys, observed in the cadmium exclusively administered groups showed hemorrhagic necrosis in glomeruli, swelling of tubules, epithelial shedding and necrosis of tubules; however, only mild tissue lesions were observed in the cadmium and Gamdutang mixture-administered groups. Given the above results, Gamdutang is deemed to have the effects of reducing the accumulation of cadmium in blood, liver, and testis when low-concentration cadmium is administered to rats.

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References

  1. Sendelbach, L. E. and Klaassen, C. D. : Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium. metallothionein. Toxicology and Applied Pharmacology, 92, 95-102, 1988 https://doi.org/10.1016/0041-008X(88)90231-1
  2. Hammond, P. B. and Foulkes, E. C. : Metal ion toxicity in man and animals. In ; H Siegel (ed), metal ions in biological systems. Vol. 20, Marcel Dekker, New York, p177, 1986
  3. Lee, J. W., Jang, B. K., Pack, J. A., Pack, J. Y., Kim, W. J. and Woo K. M. : The mechanism of the neurotoxicity induced by cadmium. Korean Journal of Environmental Toxicology, 19(3), 279-286, 2004
  4. Cho, Y. C. : In vitro magnetometry, LDH activity and apoptosis as indices of cytotoxicity in alveolar macrophages exposed to cadmium chloride. Korean Journal of Environmental Health, 26(4), 115-121, 2000
  5. Dudley, R. E., Svoboda, D. J. and Klaassen, C. D : Acute exposure to cadmium causes severe liver injury in rat. Toxicology and Applied Pharmacology, 65, 302, 1982 https://doi.org/10.1016/0041-008X(82)90013-8
  6. Kim, E. J., Kim, S., Yang, E. J., Han, S. R., Kim, S. I. and Kim, W. S. : A study on the congenital anomalies induced by cadmium chloride. Korean Journal of Physical Anthropologists, 13(2), 239-251, 2000 https://doi.org/10.11637/kjpa.2000.13.2.239
  7. Webster, W. S. : Cadmium induced fetal growth retardation in the mouse. Archives of Environmental and Occupational Health, 32, 16-22, 1978
  8. Klassen, C. D., Amdur, M. O. and Doull, J. : Casaret and Doull's Toxicology, 3rd ed., Macmillan, p23-100, 1986
  9. Ando, M., Matsui, S., Jinno, H. and Takeda, M. : Urinary excretion of cyclic AMP in cadmiumintoxicated rats. Journal of Toxicology and Environmental Health, 27, 307-315, 1989 https://doi.org/10.1080/15287398909531302
  10. Prasada Rao R. V. V., Jordan, S. A. and Bhatnagar, M. K. : Combined nephrotoxicity of methylmercury lead and cadmium in pekin ducks, metallothionein, metalinteractions, and histopathology. Journal of Toxicology and Environmental Health, 26, 327-348, 1989 https://doi.org/10.1080/15287398909531257
  11. Hamer, D. H. : Metallothionein. Annual Review of Biochemistry, 55, 913-951, 1986 https://doi.org/10.1146/annurev.bi.55.070186.004405
  12. Onosaka, S., Tanaka, K. and Cherian, M. G : Effects of cadmium and zinc on tissue of metallothionein. Journal of Environmental Health Perspectives, 54, 67-72, 1984 https://doi.org/10.2307/3429792
  13. Nomiyama, K. and Nomiyama, H. : Aggravated toxicities of cadmium chloride and mercury(II) chloride in zinc deficient rats. Acta Pharmacological Toxicology Supplement, 59(7), 75-78, 1986
  14. Ahokas, R. A., Dilts, P. V. and Lahaye, E. B. : Cadmium induced fetal growth retardation: Protective effect of excess dietary zinc. American Journal of Obstetrics and Gynecology, 136, 216-221, 1980 https://doi.org/10.1016/0002-9378(80)90599-2
  15. Schroeder, H. A., Frost, D. V. and Balassa, J. J. : Essential trace metals in man. Selenium. Journal of Chronic Diseases, 23, 227-243, 1970 https://doi.org/10.1016/0021-9681(70)90003-2
  16. Suh, E. S. and Lim, J. P. : Effects of Yukmijihwang- Tang on the Hepatic Microsomal Function of Cdpoisoned Rat. Korean Journal of Pharmacognosy, 30(3), 250, 1999
  17. Lee, S. D. : A Study on the preventive effect of Kamdoo decoction on the subacute lead toxicity in rats. Graduate School of Public Health Seoul National University, 1993
  18. Chung, S. H. : Effects of Glycyrrhizae Radix and Semen Glycine extraction the hepatic injuries induced by $CCl_4$ in rats. Graduate School of Public Health Chungnam National University, 1999
  19. Han, S. H. : Antitumor activity of Gamdutang aquaacupuncture solution. Graduate School of Oriental Medicine Dongguk University, 1999
  20. Committee for Translating Donguibogam into Korean : Donguibogam. Namsandang. 1994
  21. Rho, J. H., Han, C. K., Seong, K. S. and Lee, N. H. : Effects of pork on cadmium detoxification in rats. Korean Journal of the Food Science and Animal Resources, 25(4), 373-382, 2005
  22. Choi, S. I., Lee, J. H. and Lee, S. R.: Effect of Green tea beverage for the removal of cadmium and lead by animal experiments. Korean Journal of the Food Science and Technology, 26(6), 745-749, 1994
  23. Cantilena, L. R. and Klassen, C. D. : Decreased effectiveness of chelation theraphy with after acute cadmium poisoning. Toxicology and Applied Pharmacology 43, 173-180, 1982
  24. Combs, D. K., Goodrich, R. D. and Meiske, J. C. : Influence and dietary zinc of cadmium on hair and tissue mineral concentration in rat and goats. Journal of Animal Science, 56, 184-193, 1983 https://doi.org/10.2527/jas1983.561184x
  25. Sharma, R. P, and Street, J. C. : Public health aspects of toxic heavy metals in animal feed. American Journal of Veterinary Medical Association, 177, 149-153, 1980
  26. Agarwal, A. K. : Metabolic alterations in liver and testes of adult and new born rats following cadmium administration. Bulletin of Environmental Contamination and Toxicology, 40, 569-575, 1988 https://doi.org/10.1007/BF01688382
  27. Dudley, R. E., Gammal, L. M. and Klaassen, C. D. : Cadmium-induced hepatic cadmium metallothionein in nephrotoxicity. Toxicology and Applied Pharmacology, 77, 414-426, 1985 https://doi.org/10.1016/0041-008X(85)90181-4
  28. Kim, P. G. : Effects of Garlic Oil (diallyl disulfide)/Vitamin A (retinal acetate) on heat shock protein induction in cadmium treated rats. Journal of Food Hygiene and Safety, 13(2), 171-187, 1998
  29. Nishizumi, M. : Electron microscopic study of cadmium nephrotoxicity in the rat. Archives of Environmental and Occupational Health, 24, 215-225, 1972 https://doi.org/10.1080/00039896.1972.10666072
  30. Jang, J. S. and Kwon, O. D., : Histopathological studies on the effect of Korean Safflower (Carthamus tinctorious L.) seed powder on cadmium poisoning in mice. Journal of Veterinary Clinical Medicine, 18(2), 116-123, 2001