한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제18권2호
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- Pages.120-123
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- 2008
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
토끼에서 나린진이 니모디핀의 생체이용률에 미치는 영향
Effects of Naringin on the Bioavailability of Nimodipine in Rabbits
- Choi, Dong-Hyun (College of Medicine, Chosun University) ;
- Kim, Hyun-Yong (College of Pharmacy, Chosun University) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun University)
- 발행 : 2008.12.31
초록
The purpose of this study was to investigate the effect of naringin, one of flavonoids, on the pharmacokinetics and bioavailability of nimodipine in rabbits. Pharmacokinetic parameters of nimodipine were determined in rabbits after oral administration of nimodipine (16 mg/kg) with or without naringin (1, 5 or 15 mg/kg). Nimodipine was analyzed by high performance liquid chromatography using Hypersil ODS column. Naringin significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) and the peak concentration (