Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
권호 표지

Relationship between Ferric Reducing Antioxidant Power and Metabolic Risk Factors in Korean Women Living in Seoul

서울지역 일부 성인 여성에서 혈청 Ferric Reducing Antioxidant Power와 대사 위험요인간의 상관성에 대한 연구

  • Kwak, Ho-Kyung (Department of Home Economics, Korea National Open University) ;
  • Lee, Mee-Sook (CoreMed Co. Ltd., Healthcare Company) ;
  • Lim, So-Young (Department of Food and Nutrition, Yonsei University) ;
  • Yoon, Sun (Department of Food and Nutrition, Yonsei University)
  • 곽호경 (한국방송통신대학교 가정학과) ;
  • 이미숙 ((주)코어메드) ;
  • 임소영 (연세대학교 식품영양학과) ;
  • 윤선 (연세대학교 식품영양학과)
  • Published : 2008.02.29
Download PDF
⟨ Previous Next ⟩

Abstract

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

Keywords

References

  1. Ahn NY, Shin YJ, Kim KJ (2005): Blood lipids concentration and body composition as the different age in obese women. J Korean Physical Edu Assoc for Girls and Women 19(1): 55-65
  2. Alberti KG, Zimmet PZ (1998): Definition, diagnosis and classification of diabetes mellitus and its complications. Part I: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7): 539-553 https://doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
  3. Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Venneria E, O'Connor JM, Maiani G, Coudray C, Roussel AM (2005): Agerelated oxidative stress and antioxidant parameters in middle - aged and older European subjects: the ZENITH study. Eur J Clin Nutr 59: S58-62 https://doi.org/10.1038/sj.ejcn.1602300
  4. Astaneie F, Afshari M, Mojtahedi A, Mostafalou S, Zamani MJ, Larijani B, Abdollahi M (2005): Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res 36(4): 376-381 https://doi.org/10.1016/j.arcmed.2005.03.007
  5. Bae HS (2006): Body mass index, dietary intake, serum lipids and antioxidant status of young females. Korean J Comm Nutr 11(4): 479-487
  6. Baynes JW (1991): Role of oxidative stress in development of complications in diabetes. Diabetes 40(4): 405-12 https://doi.org/10.2337/diabetes.40.4.405
  7. Benzie IF, Strain JJ (1996): The Ferric Reducing Ability of Plasma (FRAP) as a Measure of 'Antioxidant Power': The FRAP Assay. Anal Biochem 239(1): 70-76 https://doi.org/10.1006/abio.1996.0292
  8. Benzie IF, Strain JJ (1999): Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299: 15-27 https://doi.org/10.1016/S0076-6879(99)99005-5
  9. Benzie IF, Szeto YT (1999): Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. J Agric Food Chem 47(2): 633-6 https://doi.org/10.1021/jf9807768
  10. Benzie IF, Szeto YT, Strain JJ, Tomlinson B (1999): Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer 34(1): 83-7 https://doi.org/10.1207/S15327914NC340112
  11. Cangemi R, Angelico F, Loffredo L, Del Ben M, Pignatelli P, Martini A, Violi F (2007): Oxidative stress-mediated arterial dysfunction in patients with metabolic syndrome: Effect of ascorbic acid. Free Radic Biol Med 43(5): 853-859 https://doi.org/10.1016/j.freeradbiomed.2007.06.002
  12. Cao G, Prior RL (1998): Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem 44(6): 1309-1315
  13. Collins JK, Arjmandi BH, Claypool PL, Perkins-Veazie P, Baker RA, Clevidence BA (2004): Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults. Nutr J 3: 15 https://doi.org/10.1186/1475-2891-3-15
  14. deGraft-Johnson J, Kolodziejczyk K, Krol M, Nowak P, Krol B, Nowak D (2007): Ferric-reducing ability power of selected plant polyphenols and their metabolites: Implications for clinical studies on the antioxidant effects of fruits and vegetable consumption. Basic Clin Pharmacol Toxicol 100(5): 345-352 https://doi.org/10.1111/j.1742-7843.2007.00056.x
  15. Demirbag R, Yilmaz R, Gur M, Celik H, Guzel S, Selek S, Kocyigit A (2006): DNA damage in metabolic syndrome and its association with antioxidative and oxidative measurements. Int J Clin Pract 60(10): 1187-1193 https://doi.org/10.1111/j.1742-1241.2006.01042.x
  16. Hikita M, Ohno I, Mori Y, Ichida K, Yokose T, Hosoya T (2007): Relationship between hyperuricemia and body fat distribution. Intern Med 46(17): 1353-1358 https://doi.org/10.2169/internalmedicine.46.0045
  17. Kashyap MK, Yadav V, Sherawat BS, Jain S, Kumari S, Khullar M, Sharma PC, Nath R (2005): Different antioxidants status, total antioxidant power and free radicals in essential hypertension. Mol Cell Biochem 277: 89-99 https://doi.org/10.1007/s11010-005-5424-7
  18. Kim AJ, Kim HB, Bang IS, Kim SY (2006): The effects of mulberry fruit extract supplementation on the serum mineral contents and oxidative stress markers of middle-aged humans living in Choongnam area. Korean J Food Sci Technol 38(2): 284-289
  19. Kim SH, Chang MJ, Kee SG, Chang WS, Choi HH, Sung JH (2003): The effect of ginseng administration on malondialdehyde and total antioxidant status of the blood in human. Korean J Physical Edu 42(3): 661-668
  20. Kim SK, Park YS, Byon KE (2000): Comparison of the total antioxidant status and usual dietary intake in normal and overweight males. Korean J Comm Nutr 5(4): 633-641
  21. Kuppusamy UR, Indran M, Ahmad T, Wong SW, Tan SY, Mahmood AA (2005a): Comparison of oxidative damage in Malaysian endstage renal disease patients with or without non-insulindependent diabetes mellitus. Clin Chim Acta. 351(1-2): 197-201 https://doi.org/10.1016/j.cccn.2004.09.014
  22. Kuppusamy UR, Indran M, Rokiah P (2005b): Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients. Diabet Med 22(10): 1343-1346 https://doi.org/10.1111/j.1464-5491.2005.01630.x
  23. Kwak HK, Yoon S (2005): Relation of serum oxygen radical absorbance capacity with metabolic risk factors in human volunteers. J Comm Nutr 7(4): 215-219
  24. Lee SA, Woo JH, Paik IY (2004): Effects of cross application of endurance and resistance excercise on tissue damage and antioxidant system in soccer players and bodybuilders. Exercise Science 13(4): 423-434
  25. Lopes HF, Martin KL, Nashar K, Morrow JD, Goodfriend TL, Egan BM (2003): DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity. Hypertension 41(3): 422-430 https://doi.org/10.1161/01.HYP.0000053450.19998.11
  26. Ministry of Health and Welfare (2007): The Third Korea National Health & Nutrition Examination Survey -Health Examination
  27. Mutlu-Turko lu U, Akalin Z, lhan E, Yilmaz E, Bilge A, Ni anci Y, Uysal M (2005): Increased plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in patients with angiographically defined coronary artery disease. Clin Biochem 38: 1059-1065 https://doi.org/10.1016/j.clinbiochem.2005.07.001
  28. Mutlu-Tuko lu U lhan E, Oztezcan S, Kuru A, Ayka -Toker G, Uysal M (2003): Age-related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects. Clin Biochem 36: 397-400 https://doi.org/10.1016/S0009-9120(03)00035-3
  29. Nagyova A, Krajcovicova-Kudlackova M, Horska A, Smolkova B, Blazicek P, Raslova K, Collins A, Dusinska M (2004): Lipid peroxidation in men after dietary supplementation with a mixture of antioxidant nutrients. Bratisl Lek Listy 105(7-8): 277-80
  30. Nowak M, Swietochowska E, Wielkoszy ski T, Marek B, Karpe J, Górski J, G ogowska-Szelag J, Kos-Kud a B, Ostrowska Z (2003): Changes in blood antioxidants and several lipid peroxidation products in women with age-related macular degeneration. Eur J Ophthalmol 13(3): 281-286 https://doi.org/10.1177/112067210301300307
  31. Park YH, Rhee CS, Lee YC (1993): Distribution patterns of serum lipids by age and the relation of serum lipids to degree of obesity and blood pressure in korean adults. Korean J Lipid 3(2): 165-180
  32. Pialoux V, Mounier R, Ponsot E, Rock E, Mazur A, Dufour S, Richard R, Richalet J-P, Coudert J, Fellmann N (2006): Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. Eur J Clin Nutr 60(12): 1345-1354 https://doi.org/10.1038/sj.ejcn.1602462
  33. Redon J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A, Saez GT (2003): Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension 41(5): 1096-1101 https://doi.org/10.1161/01.HYP.0000068370.21009.38
  34. Rizvi SI, Jha R, Maurya PK (2006): Erythrocyte plasma membrane redox system in human aging. Rejuvenation Res 9(4): 470-475 https://doi.org/10.1089/rej.2006.9.470
  35. Rodrigo R, Bächler JP, Araya J, Prat H, Passalacqua W (2007): Relationship between (Na + K)-ATPase activity, lipid peroxidation and fatty acid profile in erythrocytes of hypertensive and normotensive subjects. Mol Cell Biochem 303(1-2): 73-81 https://doi.org/10.1007/s11010-007-9457-y
  36. Rosell M, Regnström J, Kallner A, Hellenius ML (1999): Serum urate determines antioxidant capacity in middle-aged men - a controlled, randomized diet and exercise intervention study. J Intern Med 246: 219-226 https://doi.org/10.1046/j.1365-2796.1999.00522.x
  37. Sharifian A, Farahani S, Pasalar P, Gharavi M, Aminian O (2005): Shift work as an oxidative stressor. J Circadian Rhythms 3:15 DOI:10.1186/1740-3391-3-15
  38. Touyz RM (2003): Reactive oxygen species in vascular biology : role in arterial hypertension. Expert Rev Cardiovasc Ther 1: 91-106 https://doi.org/10.1586/14779072.1.1.91
  39. Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, Desouza CA (2006): Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity 14(12): 2127-2131 https://doi.org/10.1038/oby.2006.248
  40. Vassalle C, Masini S, Carpeggiani C, L'Abbate A, Boni C, Zucchelli GC (2004): In vivo total antioxidant capacity: comparison of two different analytical methods. Clin Chem Lab Med 42(1): 84-89 https://doi.org/10.1515/CCLM.2004.016
  41. World Health Organization, International Association for the study of Obesity & International Obesity Task Force (2000): The Asia- Pacific Perspective: Redefining obesity and its treatment, Health Communications Australia Pty Limited, Geneva