Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
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Effects of Medical Nutrition Therapy on Dietary Quality, Plasma Fatty Acid Composition and Immune Parameters in Atopic Dermatitis Patients

아토피 피부염 환자에서 12 주간의 심층 영양관리에 따른 식사의 질과 혈중 지방산조성 및 면역지표에 관한연구

  • Kim, Bang-Shil (Dept. of Medical Nutrition, Graduate School of East-West Medical Science) ;
  • Kim, Yun-Young (Research Institute of Clinical Nutrition) ;
  • Park, Jin-Hee (Dept. of Medical Nutrition, Graduate School of East-West Medical Science) ;
  • Kim, Nack-In (Dept. of Dermatology, College of Medicine, Kyung Hee University) ;
  • Choue, Ryo-Won (Dept. of Medical Nutrition, Graduate School of East-West Medical Science)
  • 김방실 (경희대학교 동서의학대학원 의학영양학과) ;
  • 김윤영 (임상영양연구소) ;
  • 박진희 (경희대학교 동서의학대학원 의학영양학과) ;
  • 김낙인 (경희대학교 의과대학 피부과학교실) ;
  • 조여원 (경희대학교 동서의학대학원 의학영양학과)
  • Published : 2008.02.29
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Abstract

Atopic dennatitis (AD) is one of the major public health problem. It has been reported that the prevalence of AD in children and adults are 10-20% and 1-3%, respectively. Westernization of food habits, urbanization, and environmental pollution are contributing factors toward the recent rise in prevalence. Excessive dietary restriction leads to chronic malnutrition in atopic dermatitis patients. The purpose of this study was to investigate the effects of medical nutrition therapy (MNT) on quality of diet and blood immune parameters in atopic dermatitis patients. The 19 atopic dermatitis patients (7 men and 12 women) admitted to K University Medical Center were studied. During the 12 weeks of intervention, the subjects were given MNT by a dietitian for 30-45 minutes every other week. MNT was comprised with general dietary therapy, intake of balanced meals, emphasis on n-3 fatty acid contents in foods, and food allergies. Anthropometric and dietary assessment and blood analysis were taken at baseline and after 12 weeks of MNT. After 12 weeks of MNT, the subjects' dietary qualities, including dietary diversity score (DDS), meal balance score (MBS) and dietary variety score (DVS) were significantly increased (p < 0.05). According to significantly increased intake of EPA and DHA, dietary n-6/n-3 fatty acid ratio decreased to the recommended level for the atopic dermatitis patients (p < 0.05). These changes of dietary fatty acid consumption were reflected erythrocyte fatty acid composition. After 12 weeks of MNT, serum levels of IgE and IL-4 levels were significantly decreased, however, the levers of INF-$\{gamma}$, WBC, lymphocyte and TLC were not changed. As a conclusion, the individualized MNT improved the quality of diet in atopic dermatitis patients thereby influenced RBC fatty acid composition and IgE and IL-4 levels.

Keywords

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