Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Expression of Endoplasmic Reticulum Membrane Kinases by Thyroid Stimulating Hormone in the FRTL-5 Cells

  • Jin, Cho-Yi (Molecular Cell Biology Lab., Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Kwon, Ki-Sang (Molecular Cell Biology Lab., Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Han, Song-Yi (Molecular Cell Biology Lab., Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
  • Kwon, O-Yu (Molecular Cell Biology Lab., Department of Anatomy, College of Medicine, Chungnam National University)
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  • 권오유 (충남대학교 의과대학 해부학교실 분자세포생물학연구실)
  • Published : 2008.03.31
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Abstract

This experiment was performed to study the effect of TSH (thyroid-stimulating hormone) on the expression of endoplasmic reticulum (ER) chaperones in the rat thyrocytes FRTL-5 cells. Although the expressions of ER membrane kinases (ATF6, IRE1 and PERK) were specially enhanced under absence of TSH, no remarkable up- or down regulations of ER chaperones (BiP, CHOP and Calnexin) were detected by TSH. We firstly report here that TSH by dose up-regulated expression of ER membrane kinases in FRTL-5 culture thyrocytes.

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