외상 후 스트레스 장애의 신경기반 : 부적점화과제와 기능자기공명영상 연구

Neural Substrates of Posttraumatic Stress Disorder : Functional Magnetic Resonance Imaging Study Using Negative Priming Task

  • 이병택 (서울대학교 심리과학연구소) ;
  • 유정 (서울내러티브 연구소) ;
  • 이동훈 (인디애나대학교 심리학과) ;
  • 손명호 (조지워싱턴대학교 심리학과) ;
  • 강내희 (중앙대학교 영어영문학과) ;
  • 함병주 (한림대학교 의과대학 한강성심병원 정신과학교실) ;
  • 최남희 (서울내러티브 연구소)
  • Lee, Byeong-Taek (Institute of Psychological Science, Seoul National University) ;
  • Ryu, Jeong (Seoul Institute for Narrative Studies) ;
  • Lee, Dong Hoon (Department of Psychology, Indiana University) ;
  • Sohn, Myeong-Ho (Department of Psychology, George Washington University) ;
  • Kang, Nae Hee (Department of English Language and Literature, Chung Ang University) ;
  • Ham, Byung-Joo (Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medial Center) ;
  • Choi, Nam Hee (Seoul Institute for Narrative Studies)
  • 발행 : 2008.05.31

초록

Objectives : Posttraumatic stress disorder(PTSD) has been primarily associated with emotional problems. Recently, however, the impact of PTSD on cognitive processes has interested a growing number of researchers. The current study is aimed at investigating the cognitive aspects of PTSD at both behavioral and neurological levels. Methods : We recruited individuals with PTSD who survived the Daegu subway explosion in 2003 as well as non-PTSD individuals as a control group. To evaluate the inhibitory processes and the neural mechanisms, we had these individuals perform the negative priming task simultaneously with functional MRI scanning. Results : Behaviorally, the negative priming effect was intact in the control group but was not evident in the PTSD group. In the imaging results, only the PTSD group showed the negative priming effect (i.e., increased activation of the negative priming condition as opposed to the neutral condition) in the dorsolateral prefrontal cortex, anterior cingulate cortex, and inferior temporal gyrus. The PTSD group also showed increased activity for the positive priming condition as opposed to the neutral condition in the claustrum. These results confirm and extend the previous findings that the integrity of the ACC is compromised in the trauma survivors due to disrupted white matter tract. Conclusions : The current results suggest that deteriorated performance of the PTSD group may be due to the functional problem as well as the structural abnormalities.

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