Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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The Effect of Adjusted Water Fluoridation on Bone Mineral Density

수돗물불소농도조정사업이 지역주민의 골밀도에 미치는 영향

  • Han, Yoon-Jung (Department of Environmental Health School of Public Health and Institute of Health and Environment, Seoul National University) ;
  • Min, Jin-Young (Department of Environmental Health School of Public Health and Institute of Health and Environment, Seoul National University) ;
  • Han, Dong-Hun (Department of Preventive and Community Dentistry, Pusan National University) ;
  • Kim, Hyun-Duck (Department of Preventive and Social Dentistry, Seoul National University) ;
  • Paek, Do-Myung (Department of Environmental Health School of Public Health and Institute of Health and Environment, Seoul National University)
  • 한윤정 (서울대학교 보건대학원, 보건환경연구소) ;
  • 민진영 (서울대학교 보건대학원, 보건환경연구소) ;
  • 한동헌 (부산대학교 치과대학) ;
  • 김현덕 (서울대학교 치과대학) ;
  • 백도명 (서울대학교 보건대학원, 보건환경연구소)
  • Published : 2008.08.30
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Abstract

Adjusted water fluoridation has been disputed because of its various effects on human health. Previous studies have been concerned with the difference in bone mineral density (BMD) between water fluoridated (WF) and none water fluoridated (NWF) districts. The aim of this study is to examine whether water fluoridation affects BMD. BMD was measured by dual energy X-ray absorptiometry (DXA). 386 adults(174 males and 212 females) in Ansan (WF) district and 399 adults (176 males and 223 females) in Sihwa (NWF) district, participated in this study. The Ansan and Sihwa districts are similar in residential environment and living class. The relationship between serum fluoride concentration and BMD was also examined by analysis of the serum fluoride concentrations from 402 inhabitants of the Ansan district. In females, the BMD of subjects living in Ansan ($0.457{\pm}0.008$) was a little higher than that of Sihwa subjects ($0.446{\pm}0.008$), although it is not significant, after adjusting for BMI, physical activity level, educational achievement, smoking volume, menopause status, and number of births. However, the BMD of Ansan subjects ($0.532{\pm}0.020$) in their forties was statistically higher than that of Sihwa (0.498{\pm}0.019). No relationship was found in males. In residential periods, there was significant difference (Ansan $0.467{\pm}0.013$, Sihwa $0.434{\pm}0.012$, p=0.0125) in the BMD between females of two districts, particularly in the group of over 6 year long-term inhabitants. On the contrary, there was no remarkable difference in males from the two districts. Serum fluoride concentrations in females were associated with BMD, especially in the age group of forties (p=0.0457). No relationship was observed in the male group. Analysis of adult BMD over the age of 20 in a water fluoridated and a none water fluoridated district, confirms more or less a higher BMD in the water fluoridated (WF) district, especially for females. It is assumed that the difference between two districts came somewhat from the effect of water fluoridation.

Keywords

References

  1. Lee, I . K. and Kim, J. G. : A survey on the contents of fluoride, calcium, and magnesium of reservoir water on a stream in the Jeon-buk area of Korea. Korean Journal of Environmental Health, 29(2), 38-44, 2003
  2. Kroger, H., Alhava, E., Honkanen, R., Tuppurainen, M. and Saarikoski, S. : The effect of fluoridated drinking water on axial bone mineral density--a population- based study. Bone and Mineral, 27(1), 33-41, 1994 https://doi.org/10.1016/S0169-6009(08)80184-5
  3. Arno ld, C. M ., B ailey, D . A., Faulkner, R. A ., McKay, H. A. and McCulloch, R. G. : The effect of water fluoridation on the bone mineral density of young women. Canadian Journal of Public Health, 88(6), 388-391, 1997
  4. Sowers, M., Whitford, G. M., Clark, M. K. and Jannausch, M. L. : Elevated serum fluoride concentrations in women are not related to fractures and bone mineral density. The Journal of Nutrition, 135(9), 2247-2252, 2005
  5. Cauley, J. A., Murphy, P. A., Riley, T. J. and Buhari, A. M. : Effects of fluoridated drinking water on bone mass and fractures: The study of osteoporotic fractures. Journal of Bone and Mineral Research, 10(7), 1076-1086, 1995 https://doi.org/10.1002/jbmr.5650100712
  6. Phipps, K. R., Orwoll, E. S., Mason, J. D. and Cauley, J. A. : Community water fluoridation, bone mineral density, and fractures: Prospective study of effects in older women. British Medical Journal, 321(7265), 860-864, 2000 https://doi.org/10.1136/bmj.321.7265.860
  7. Riggs, B. L., Hodgson, S. F., O'Fallon, W. M., Chao, E. Y., Wahner, H. W., Muhs, J. M., Cedel, S. L. and Melton, L. J. 3rd. : Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. The New England Journal of Medicine, 322(12), 802-809, 1990 https://doi.org/10.1056/NEJM199003223221203
  8. Farley, S. M., Wergedal, J. E., Farley, J. R., Javier, G. N ., S chulz, E. E., Talbo t, J . R., Libanati, C . R., Lindegren, L., Bock, M., Goette, M. M., Mohan, S. S., Kimball-Johnson, P., Perkel, V. S., Cruise, R. J. and Baylink, D. J. : Spinal fractures during fluoride therapy for osteoporosis: relationship to spinal bone density. Osteoporosis International, 2(5), 213-218, 1992 https://doi.org/10.1007/BF01624143
  9. Rubin, C. D., Pak, C. Y., Adams-Huet, B., Genant, H. K., Li, J. and Rao, D. S. : Sustained-release sodium fluoride in the treatment of the elderly with established osteoporosis. Archives of Internal Medicine, 161(19), 2325-2333, 2001 https://doi.org/10.1001/archinte.161.19.2325
  10. Hedlund, L. R. and Gallagher, J. C. : Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. Journal of Bone and Mineral Research, 4(2), 223-225, 1989 https://doi.org/10.1002/jbmr.5650040214
  11. Cho, S. H., Kwon, H. J., Ha, M. N., Ha, E. H. and Hong, Y. C. : Medical scientific research on human health effect derived from adjusted water fluoridation. Korean Medical Association Research Report. Seoul National University Medical Research Center Institute of Environmental Medicine, 1999
  12. Moon, M. S., Cho, S. H., Ahn, H. S., Kim, J. B. and Sung, J. H. : Research for effect-assessment on adjusted water fluoridation. Ministry of Health and Welfare. 2000
  13. Kang, J. W. : Medical research for human health effect on adjusted water fluoridation. Korean Medical Association Research Report, 2003
  14. Jones, T. and Davie, M. W. : Bone mineral density at distal forearm can identify patients with osteoporosis at spine or femoral neck. British Journal of Rheumatology, 37(5), 539-543, 1998 https://doi.org/10.1093/rheumatology/37.5.539
  15. Fordham, J. N., Chinn, D. J. and Kumar, N. : Identification of women with reduced bone density at the lumbar spine and femoral neck using BMD at the os calcis. Osteoporosis International, 11(9), 797-802, 2000 https://doi.org/10.1007/s001980070059
  16. Marshall, D., Johnell, O. and Wedel, H. : Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. British Medical Journal, 312(7041), 1254-1259, 1996 https://doi.org/10.1136/bmj.312.7041.1254
  17. Min, J. Y., Min, K. B., Paek, D. and Cho, S. I. : Side differences in the bone density of the distal radius and calcaneus in Koreans aged 4-86 years. Journal of Clinical Densitometry, 10(2), 184-188, 2007 https://doi.org/10.1016/j.jocd.2006.12.004
  18. Nakamura, K., Tanaka, Y., Saitou, K., Nashimoto, M. and Yamamo to, M. : Age and sex d ifferences in the bone mineral density of the distal forearm based on health check-up data of 6343 Japanese. Osteoporosis International, 11(9), 772-777, 2000 https://doi.org/10.1007/s001980070056
  19. Orwoll, E. S., Belknap, J. K. and Klein, R. F. : Gender specificity in the genetic determinants of peak bone mass. Journal of Bone and Mineral Research, 16(11), 1962-1971, 2001 https://doi.org/10.1359/jbmr.2001.16.11.1962
  20. The Korean Society of Bone Metabolism. Osteoporosis, 2nd edition, Seoheong, Seoul, 1, 2000
  21. The Korean Society of Bone Metabolism. Osteoporosis, 3rd edition, Hanmi Medical, Seoul, 249, 2006
  22. Lahti, S. M., Uusitalo, U., Feskens, E., Haw, U., Tuo milehto, J. a nd L uo ma, H. : F luo ride a nd s ugar intake among adults and youth in Mauritius: preliminary results. Advances in Dental Research, 9(1), 21-25, 1995
  23. Chowdhury, N. G., Brown, R. H. and Shepherd, M. G. : Fluoride intake of infants in New Zealand. Journal of Dental Research, 69(12), 1828-1833, 1990 https://doi.org/10.1177/00220345900690120801
  24. Lee, J. H. : A study on the fluoride intake from routine diets in fluoridated area & the pollution level of fluoride compounds for water fluoridation. Korean Institute of Oral Health Services, 2004
  25. Jung, S. H., Ma, D. S., Ryu, J. I., Hwang, J. H. and Kho, Y. L. : Fluoride intake by the duplicate-diet technique and urinary excretion in Korean children aged 3-6 years. Korean Journal of Environmental Health, 31(6), 475-482, 2005