Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Antioxidative Effects of Phellinus linteus Extract

상황버섯 추출물의 항산화 효과

  • Rhyu, Dong-Young (Department of Medical Plant Resources, Mokpo National University) ;
  • Kim, Min-Suk (Department of Medical Plant Resources, Mokpo National University) ;
  • Min, Oh-Jin (Department of Medical Plant Resources, Mokpo National University) ;
  • Kim, Dong-Wook (Department of Medical Plant Resources, Mokpo National University)
  • 류동영 (목포대학교 자연과학대학 생명과학부목포대학교 자연과학대학 생명과학부 생약자원) ;
  • 김민석 (목포대학교 자연과학대학 생명과학부목포대학교 자연과학대학 생명과학부 생약자원) ;
  • 민오진 (목포대학교 자연과학대학 생명과학부목포대학교 자연과학대학 생명과학부 생약자원) ;
  • 김동욱 (목포대학교 자연과학대학 생명과학부목포대학교 자연과학대학 생명과학부 생약자원)
  • Published : 2008.02.27
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Abstract

Reactive oxygen species(ROS) or free radical-mediated oxidative stress plays an important role in the pathophysiologic process of disease state. This study investigated antioxidative effects of Phellinus linteus extract on the generation of 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, superoxide anion radical(${O_2}^-$), hydroxyl radical(${\cdot}OH$), nitric oxide(NO), and peroxynitrite($ONOO^-$) radical and free radical-mediated protein oxidation under in vitro assay systems. This results showed that Phellinus linteus extract effectively inhibited the generation of free radicals in the all assay system with dose-dependent manner and also significantly reduced the protein oxidative level. Thus, the present study indicates that Phellinus linteus extract possesses a potent antioxidant activity and plays a beneficial role against free radical-induced oxidative injury.

본 연구에서는 ${O_2}^-,{\cdot}OH$ radical, NO, $ONOO^-$ 자유라디칼을 유발시키는 in vitro assay system과 free radical-induced oxidative stress에 의한 단백질 손상에 대한 진흙버섯속에 속하는 상황버섯 물 추출물의 항산화 효과를 측정하였다. 상황버섯 물 추출물의 ${O_2}^-,{\cdot}OH$ radical, NO, $ONOO^-$ 자유라디칼 억제효과에서는 실험에 사용된 양성 대조물 보다는 낮게 나타났으나 모든 실험계에서 대조군에 비해 뚜렷하게 자유라디칼 소거효과를 나타냈다. 또한 상황버섯 물 추출물은 산화적 스트레스에 의한 단백질 손상 억제효과에서도 대조군에 비해 명확한 저해효과를 나타냈다. 그러므로 상황버섯의 항산화 효과는 상황버섯의 약리학적 효능을 설명하는데 중요한 기초 자료라고 사료된다.

Keywords

References

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