Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지

Kinetic Analysis of the MAPK and PI3K/Akt Signaling Pathways

  • Suresh, Babu CV (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Babar, Sheikh Md. Enayetul (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Song, Eun Joo (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Oh, Eulsik (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Yoo, Young Sook (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
  • Received : 2007.08.29
  • Accepted : 2007.12.28
  • Published : 2008.05.31
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Abstract

Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.

Keywords

Acknowledgement

Supported by : Ministry of Science and Technology, Korea Institute of Science and Technology

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