Molecules and Cells

  • 제25권2호
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  • Pages.242-246
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  • 2008
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
권호 표지

Attenuated Neuropathic Pain in CaV3.1 Null Mice

  • Na, Heung Sik (Department of Physiology, Korea University College of Medicine) ;
  • Choi, Soonwook (Center for Neural Science, Korea Institute of Science and Technology) ;
  • Kim, Junesun (Department of Physiology, Korea University College of Medicine) ;
  • Park, Joonoh (Center for Neural Science, Korea Institute of Science and Technology) ;
  • Shin, Hee-Sup (Center for Neural Science, Korea Institute of Science and Technology)
  • 투고 : 2007.08.03
  • 심사 : 2007.10.31
  • 발행 : 2008.04.30
⟨ 이전 논문 다음 논문 ⟩

초록

To assess the role of $\alpha_{1G}$ T-type $Ca^{2+}$ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking $Ca_{V}3.1$ (${\alpha}_{1G}{^{-/-}}$), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The ${{\alpha}_{1G}}^{-/-}$ mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of ${\alpha}_{1G}$ T-type $Ca^{2+}$ channels in the development of neuropathic pain, and suggest that selective modulation of ${\alpha}_{1G}$ subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

키워드

과제정보

연구 과제 주관 기관 : Ministry of Science and Technology

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