The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Korean Red Ginseng in the Spinal Cord of Rats

쥐의 척수강 내로 투여한 고려 홍삼의 항통각효과에 대한 아드레날린성 및 콜린성 수용체 역할

  • Kim, Se Yeol (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Lee, Hyung Gon (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Woong Mo (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Lee, Jae Dam (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Yeo Ok (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Huang, Lan Ji (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University) ;
  • Cui, Jin Hua (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University)
  • 김세열 (전남대학교 의과대학 마취통증의학교실) ;
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 이형곤 (전남대학교 의과대학 마취통증의학교실) ;
  • 김웅모 (전남대학교 의과대학 마취통증의학교실) ;
  • 이재담 (전남대학교 의과대학 마취통증의학교실) ;
  • 김여옥 (전남대학교 의과대학 마취통증의학교실) ;
  • 황란희 (두뇌한국21사업 전남대학교 의생명 인력사업단) ;
  • 최금화 (두뇌한국21사업 전남대학교 의생명 인력사업단)
  • Received : 2008.02.22
  • Accepted : 2008.04.01
  • Published : 2008.06.01
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Abstract

Background: Experimental evidence indicates that ginseng modulate the nociceptive transmission. Authors examined the role of adrenergic and cholinergic receptors on the antinociceptive action of Korean red ginseng against the formalin-induced pain at the spinal level. Methods: Catheters were inserted into the intrathecal space of male Sprague-DawIey rats. Fifty ${\mu}l$ of 5% formalin solution was injected to the hindpaw for induction of pain and formalin-induced pain (flinching response) was observed. The role of spinal adrenergic and cholinergic receptors on the effect of Korean red ginseng was assessed by antagonists (Prazosin, yohimbine, atropine and mecamylamine). Results: Intrathecal Korean red ginseng produced a dose-dependent suppression of the flinching response in the rat formalin test. All of prazosin, yohimbine, atropine and mecamylamine antagonized the antinociception of Korean red ginseng. Conclusions: Spinal Korean red ginseng is effective against acute pain and facilitated pain state evoked by formalin injection. All of alpha 1, alpha 2, muscarinic and nicotinic receptors may play an important role in the antinociceptive action of Korean red ginseng at the spinal level.

Keywords

Acknowledgement

Supported by : 전남대학교

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