과제정보
연구 과제 주관 기관 : Korea Research Foundation
참고문헌
- Akiyama, T., Bouillet, P., Miyazaki, T., Kadono, Y., Chikuda, H., Chung, U.I., Fukuda, A., Hikita, A., Seto, H., Okada, T., et al. (2003). Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J. 22, 6653-6664 https://doi.org/10.1093/emboj/cdg635
- Bergmann, A. (2002). Survival signaling goes BAD. Dev. Cell 3, 607-608 https://doi.org/10.1016/S1534-5807(02)00328-3
- Darnell, J.E., Kerr, I.M., and Stark, G.R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421
- Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M.E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 https://doi.org/10.1016/S0092-8674(00)80405-5
- De Vos, J., Jourdan, M., Tarte, K., Jasmin, C., and Klein, B. (2000). JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br. J. Haematol. 109, 823-828 https://doi.org/10.1046/j.1365-2141.2000.02127.x
- Dijkers, P.F., Medema, R.H., Lammers, J.W., Koenderman, L., and Coffer, P.J. (2000). Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10, 1201-1204 https://doi.org/10.1016/S0960-9822(00)00728-4
- Grigoriadis, A.E., Wang, Z.Q., Cecchini, M.G., Hofstetter, W., Felix, R., Fleisch, H.A., and Wagner, E.F. (1994). c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443-448 https://doi.org/10.1126/science.7939685
- Hu, P., Han, Z., Couvillon, A.D., and Exton, J.H. (2004). Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 279, 49420-49429 https://doi.org/10.1074/jbc.M407700200
- Huang, H.M., Huang, C.J., and Yen, J.J. (2000). Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood 96, 1764-1771
- Jane, E.P., Premkurmar, D.R., and Pollack, I.F. (2007). AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. Cancer Lett. 257, 36-46 https://doi.org/10.1016/j.canlet.2007.06.020
- Jiang, X., and Wang, X. (2004). Cytochrome C-mediated apoptosis. Annu. Rev. Biochem. 73, 87-106 https://doi.org/10.1146/annurev.biochem.73.011303.073706
- Jones, R.G., Parsons, M., Bonnard, M., Chan, V.S., Yeh, W.C., Woodgett, J.R., and Ohashi, P.S. (2000). Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J. Exp. Med. 191, 1721-1734 https://doi.org/10.1084/jem.191.10.1721
- Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004). Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758-763 https://doi.org/10.1038/nature02444
- Kwak, H.B., Lee, S.W., Li, Y.J., Kim, Y.A., Han, S.Y., Jhon, G.J., Kim, H.H., and Lee, Z.H. (2004). Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH. Biochem. Pharmacol. 67, 1239-1248 https://doi.org/10.1016/j.bcp.2003.10.032
- Lee, S.E., Chung, W.J., Kwak, H.B., Chung, C.H., Kwack, K.B., Lee, Z.H., and Kim, H.H. (2001). Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J. Biol. Chem. 276, 49343-49349 https://doi.org/10.1074/jbc.M103642200
- Letai, A., Bassik, M.C., Walensky, L.D., Sorcinelli, M.D., Weiler, S., and Korsmeyer, S.J. (2002). Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2, 183-192 https://doi.org/10.1016/S1535-6108(02)00127-7
- Ley, R., Balmanno, K., Hadfield, K., Weston, C., and Cook, S.J. (2003). Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, bim. J. Biol. Chem. 278, 18811-18816 https://doi.org/10.1074/jbc.M301010200
- Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., and Wang, X. (1997). Cytochrome c and dATPdependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 https://doi.org/10.1016/S0092-8674(00)80434-1
- Lindsten, T., Ross, A.J., King, A., Zong, W.X., Rathmell, J.C., Shiels, H.A., Ulrich, E., Waymire, K.G., Mahar, P., Frauwirth, K., et al. (2000). The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389-1399 https://doi.org/10.1016/S1097-2765(00)00136-2
- Manolagas, S.C. (2000). Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21, 115-137
- Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapi dot, Z., Leeder, J.S., Freedman, M., Cohen, A., Gazit, A., et al. (1996). Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379, 645-648 https://doi.org/10.1038/379645a0
- Miyazaki, T., Katagiri, H., Kanegae, Y., Takayanagi, H., Sawada, Y., Yamamoto, A., Pando, M.P., Asano, T., Verma, I.M., Oda, H., et al. (2000). Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J. Cell Biol. 148, 333-342 https://doi.org/10.1083/jcb.148.2.333
- Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U., and Pfeffer, K. (1998). Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93, 397-409 https://doi.org/10.1016/S0092-8674(00)81168-X
- Novak, U., Harpur, A.G., Paradiso, L., Kanagasundaram, V., Jaworowski, A., Wilks, A.F., and Hamilton, J.A. (1995). Colonystimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Blood 86, 2948-2956
- Oshiro, M.M., Landowski, T.H., Catlett-Falcone, R., Hazlehurst, L.A., Huang, M., Jove, R., and Dalton, W.S. (2001). Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells. Clin. Cancer Res. 7, 4262-4271
- Pedranzini, L., Dechow, T., Berishaj, M., Comenzo, R., Zhou, P., Azare, J., Bornmann, W., and Bromberg, J. (2006). Pyridone 6, A pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 66, 9714-9721 https://doi.org/10.1158/0008-5472.CAN-05-4280
- Rho J., Takami M., and Choi, Y. (2004). Osteoimmunology: interactions of the immune and skeletal systems. Mol. Cells 17, 1-9
- Saito, K., Iwashita, J., Murata, J., and Abe, T. (2006). The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells. Anticancer Res. 26, 1085-1090
- Salvesen, G.S., and Dixit, V.M. (1997). Caspases: intracellular signaling by proteolysis. Cell 91, 443-446 https://doi.org/10.1016/S0092-8674(00)80430-4
- Sandberg, E.M., and Sayeski, P.P. (2004). Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J. Biol. Chem. 279, 34547-34552 https://doi.org/10.1074/jbc.M405045200
- Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M.E. (1998). Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95, 55-66 https://doi.org/10.1016/S0092-8674(00)81782-1
- Scheid, M.P., Schubert, K.M., and Duronio, V. (1999). Regulation of bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase. J. Biol. Chem. 274, 31108-31113 https://doi.org/10.1074/jbc.274.43.31108
- Simon, Hu., Yousefi, S., Dibbert, B., Levi-Schaffer, F., and Blaser, K. (1997). Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. 27, 3536-3539 https://doi.org/10.1002/eji.1830271256
- Takayanagi, H. (2007). Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 7, 292-304 https://doi.org/10.1038/nri2062
- Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., et al. (2000). T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408, 600-605 https://doi.org/10.1038/35046102
- Tanaka, S., Miyazaki, T., Fukuda, A., Akiyama, T., Kadono, Y., Wakeyama, H., Kono, S., Hoshikawa, S., Nakamura, M., Ohshima, Y., et al. (2006). Molecular mechanism of the life and death of the osteoclast. Ann. N. Y. Acad. Sci. 1068, 180-186 https://doi.org/10.1196/annals.1346.020
- Teitelbaum, S.L., and Ross, F.P. (2003). Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 3, 638-649
- Thompson, C.B. (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462 https://doi.org/10.1126/science.7878464
- Wang, Z.B., Liu, Y.Q., and Cui, Y.F. (2005). Pathways to caspase activation. Cell Biol. Int. 29, 489-496 https://doi.org/10.1016/j.cellbi.2005.04.001
- Weinstein, R.S., Chen, J.R., Powers, C.C., Stewart, S.A., Landes, R.D., Bellido, T., Jilka, R.L., Parfitt, A.M., and Manolagas, S.C. (2002). Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J. Clin. Invest. 109, 1041-1048 https://doi.org/10.1172/JCI0214538
- Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J., Peng, T.I., Jones, D.P., and Wang, X. (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132 https://doi.org/10.1126/science.275.5303.1129