Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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자가 말초혈조혈모세포이식 후 재발된 신경모세포종 3예에서 131I-MIBG의 고식적 치료 효과

Palliative effect of 131I-MIBG in relapsed neuroblastoma after autologous peripheral blood stem cell transplantation

  • 이용직 (영남대학교 의과대학 소아과학교실) ;
  • 하정옥 (영남대학교 의과대학 소아과학교실)
  • Lee, Yong Jik (Department of Hematology/Oncology, Yeungnam University College of Medicine) ;
  • Hah, Jeong Ok (Department of Hematology/Oncology, Yeungnam University College of Medicine)
  • 투고 : 2007.12.15
  • 심사 : 2008.01.19
  • 발행 : 2008.02.15
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초록

신경모세포종은 소아에서 발생하는 흔한 두개외 고형 종양 중 하나로서 진행된 경우 고용량 항암요법 및 자가 말초혈조혈모세포이식 후에도 재발이 잘 되어 예후가 매우 나쁘다. Iodine-131 metaiodobenzylguanidine ($^{131}I-MIBG$)는 치료에 잘 반응하지 않는 신경모세포종 4기 환자를 위한 대증적 치료 요법으로 제한적으로 이용되어 왔다. 저자들은 자가 말초혈조혈모세포이식 후 재발된 신경모세포종 3례에서 $^{131}I-MIBG$를 이용하여 통증을 경감시키고 생존 기간을 늘이는 고식적인 치료 효과를 얻어 이들에 대한 증례 보고를 하는 바이다.

Neuroblastoma is one of the most common extracranial solid tumor of childhood, and treatment of refractory neuroblastoma remains a significant clinical problem. Iodine-131-metaiodobenzylguanidine ($^{131}I-MIBG$) therapy is an alternative approach to treat stage IV neuroblastoma. We report the palliative effect of $^{131}I-MIBG$ in three cases of relapsed neuroblastoma after autologous peripheral blood stem cell transplantation. $^{131}I-MIBG$ is an effective and relatively nontoxic palliative therapy resulting in reduction of pain and prolongation of survival.

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참고문헌

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