Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

CLINICAL STUDY ON MALIGNANT MELANOMA IN ORAL CAVITY

구강내 악성흑색종에 대한 임상연구

  • Kim, Uk-Kyu (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Heo, Jin-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Hwang, Dae-Seok (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Yong-Deok (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Shin, Sang-Hun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Jong-Ryoul (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Chung, In-Kyo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 김욱규 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 허진호 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 황대석 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김용덕 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김종렬 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 정인교 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, and tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark's and Breslow's classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to analyze key determinants of outcome, We analysed 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital on recent 7 years and reviewed the literatures. Immunohistochemical study on S 100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Three patients who were treated by surgery, chemotherapy are alive, but a patients who couldn't received benefit care surgically due to poor condition was died of distant metastasis, and two patients who refused to surgery are still alive. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be considered as supporting therapy for malignant melanoma.

Keywords

References

  1. Garzino-Demo P, Fasolis M, Maggiore LT: Oral mucosal melanoma: a series of casse reports, J Cranio-facial Surg 32, 251-257, 2004 https://doi.org/10.1016/j.jcms.2003.12.007
  2. Mendenhall WM, Amdur RJ, Hinerman RW, et al: Head and Neck Mucosal Melanoma, Am J Clin Oncol 28:626-630, 2005 https://doi.org/10.1097/01.coc.0000170805.14058.d3
  3. Greene GW, Haynes JW, Dozier M, et al: Primary malignant melanoma of the oral mucosa, Oral Surg Oral Med Oral Pathol 68:1435-1441, 1953
  4. Hicks MJ, Flaitz CM: Oral mucosal melanoma:epidemiology and pathobiology, Oral Oncol 36:152-169, 2000 https://doi.org/10.1016/S1368-8375(99)00085-8
  5. Gazit D, Daniels TE: Oral melanocytic lesions:differneces in expression of HMB-45 and S-100 antigens in round and spindle cells of malignant arid benign lesions, J Oral Pathol Med 23(2): 60-64, 1994 https://doi.org/10.1111/j.1600-0714.1994.tb00257.x
  6. Manolidis S, Donald PJ: Malignant mucosal melanoma of the head and neck: Review of the literature and report of 14 patients, Cancer 80:1373-1386, 1997 https://doi.org/10.1002/(SICI)1097-0142(19971015)80:8<1373::AID-CNCR3>3.0.CO;2-G
  7. Molife R, Hancock BW: Adjuvant therapy of malignant melanoma, Crit Rev Oncol Hematol 44:81-102, 2002 https://doi.org/10.1016/S1040-8428(02)00014-8
  8. Pandey M, Mathew A, Iype EM, et al: Primary malignant mucosal melanoma of the head and neck region: pooled analysis of 60 published cases from India and review of literature, Eur J Cancer Prev 11:3-10, 2002 https://doi.org/10.1097/00008469-200202000-00002
  9. Patel SG, Prasad ML, Escrig M, et al: Primary mucosal malignant melanoma of the head and neck, Head Neck 24:247-257, 2002 https://doi.org/10.1002/hed.10019
  10. Rapini RP, Golitz LE, Greer Jr RO, et al: Primary malignant melanoma of the oral cavity, A review of 177 cases, Cancer 55:1543-1551, 1985 https://doi.org/10.1002/1097-0142(19850401)55:7<1543::AID-CNCR2820550722>3.0.CO;2-F
  11. Regezi JA, Hayward JR, Pickens TN: Superficial melanoma of oral mucous membranes, Oral Surg Oral Med Oral Pathol 45: 730-740, 1978 https://doi.org/10.1016/0030-4220(78)90148-2
  12. Umeda M, Mishima Y, Teranobu O et al: Heterogeneity of primary malignant melanomas in oral mucosa: an analysis of 43 cases in Japan, Pathology 20:234-241, 1988 https://doi.org/10.3109/00313028809059498
  13. Goerres GW, Stoeckli SJ, Schulthess GK et al: FDG PET for mucosal malignant melanoma of the head and neck, Laryngoscope, 112:381-385, 2002 https://doi.org/10.1097/00005537-200202000-00032
  14. Yii NW, Eisen T, Nicolson M, et al: Mucosal malignant melanoma of the head and neck: the Marsden experience over half a century, Clin Oncol 15: 199-204, 2003 https://doi.org/10.1016/S0936-6555(03)00068-2
  15. Stern SJ, Guillamondegui OM: Mucosal melanoma of the head and neck, Head Neck 132:22-27, 1991
  16. Prasad ML, Patel SG, Huvos AG, et al: Primary mucosal melanoma of the head and neck. A proposal for microstaging localized, stage I (lymph node-negative) tumors, Cancer 100: 1657-1664, 2004 https://doi.org/10.1002/cncr.20201