YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Salviae Radix Suppresses Mast Cell-mediated Allergic Response: Inhibition of Src-family Kinase

단삼추출물의 Src-family Kinase 억제에 의한 항앨러지 효과

  • Published : 2008.10.31
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Abstract

In this study, the anti-allergic activity and mechanim of Salviae radix (SR) were investigated. The ethanol extract of SR showed significant inhibitory effect on degranulation from antigen-stimulated mast cells and it also inhibited the expression and secretion of TNF-${\alpha}$ and IL-4 in antigen-stimulated RBL-2H3 cells. In the mast cell-mediated local animal allergy model, it suppressed the passive cutaneous anaphylaxis in a dose-dependent manner. As its mechanism of action, SR inhibited the activating phosphorylation of Syk, a downstream signaling molecule of Src-family kinase, for the activation of mast cells. The results of the study indicate that the anti-allergic activity of SR is mediated by the inhibition of Src-family kinase in mast cells.

Keywords

References

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