Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A Case of Fatal Arrhythmia after Propafenone Overdose

Propafenone 음독 후 발생한 치명적인 부정맥 1례 - 증례 보고-

  • Kyong, Yeon-Young (Department of Emergency Medicine, College of Medicine, Catholic University of Korea) ;
  • Choi, Kyoung-Ho (Department of Emergency Medicine, College of Medicine, Catholic University of Korea)
  • 경연영 (가톨릭대학교 의과대학 응급의학교실) ;
  • 최경호 (가톨릭대학교 의과대학 응급의학교실)
  • Published : 2008.12.31
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Abstract

A 36-year-old female was transferred to our emergency medical center with decreased mental status after a 6.0 g propafenone overdose because of domestic disturbance. She had no previous history of epilepsy, diabetes mellitus, hypertension or psychiatric illness. Before presenting to our center, gastrointestinal decontamination, charcoal administration, and endotracheal intubation due to bradycardia and generalized seizure had been performed. Soon after hospital arrival, at 5 h after ingestion, she collapsed into shock and fatal arrhythmia. We successfully resuscitated the patient with amiodarone, sodium bicarbonate, a large volume of normal saline, calcium, and ventilator care. At 23 h after ingestion, she was fully recovered and had no subjective signs or symptoms. To our knowledge, this is the first case report of intentional propafenone overdose in Korea, which we report with reviews of the previous literature.

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