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Effect of Korean Red Ginseng on Blood Pressure and Aortic Vascular(endothelial) Histological Changes in Rats

홍삼이 정상 흰쥐의 혈압 및 대동맥 조직 소견 변화에 미치는 영향

  • Joo, Il-Woo (Department of Family Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine) ;
  • Sung, Kyung-Hwa (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Park, Jung-Min (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lew, Jae-Hwan (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Oh, Han-Jin (Department of Family Medicine, Cheil General Hospital & Woen's Healthcare Center, Kwandong University, College of Medicine)
  • 주일우 (관동대 의과대학 제일병원 가정의학과) ;
  • 성경화 (경희대학교 동서의학대학원) ;
  • 박정민 (경희대학교 동서의학대학원) ;
  • 류재환 (경희대학교 동서의학대학원) ;
  • 오한진 (관동대 의과대학 제일병원 가정의학교실)
  • Published : 2008.12.31

Abstract

Introduction : Korean red ginseng has been shown to have an preventive effect on atheroma formation and enhancing effect on nitric oxide synthesis in endothelial cell inducing vasodilatation. However, there are few studies showing the effect of Korean red ginseng on blood pressure and vascular(endothelial) pathologic changes together. We designed this study to show changes of blood pressure and vascular pathologic findings with Korean red ginseng administration compared with Chinese red ginseng and control for 3 months in rats. Materials and methods : We studied the in vitro hypotensive effect and effect on vascular pathologic changes of Korean red ginseng compared with Chinese red ginseng and control. Rats were randomly assigned to three groups(Korean red ginseng, Chinese red ginseng and control) and evaluated by blood pressure and aortic vascular(endothelial) pathologic changes monthly during 3-month administration. All results were analyzed by paired T-test, ANOVA and post-hoc. Results : Blood pressure lowering effect was noted on Korean red ginseng and Chinese red ginseng compared to control. Especially, in Korean red ginseng group, hypotensive effect was showed in first and second month, but, in Chinese red ginseng group, it was just noted in first month. In case of vascular(aortic endothelial) pathologic finding, endothelial wall thickening and elastic fiber tearing were noted in Chinese red ginseng group compared with Korean red ginseng group and control with statistical significance.(p<0.05) Discussion : These results suggested Korean red ginseng could have more hypotensive effect and maintenance rather than Chinese red ginseng. And the difference of hypotensive effect between Korean red ginseng and Chinese red ginseng might has some association with difference of vascular pathologic findings in each group. However, further evaluation and research of other mechanism will be needed to convince this hypothesis.

1. 1개월, 2개월, 3개월 투여 시 혈압은 세 군간에 유의한 차이가 나타났으며 한국 홍삼군 및 중국 홍삼군은 대조군에 비해 혈압 감소가 나타났다.(P<0.05) 각 군별로 보면 한국 홍삼군의 경우 0-1개월, 1-2개월 사이에 혈압이 유의하게 감소하였으며, 중국 홍삼 투여군의 경우 0-1개월에만 유의한 감소를 보였다.(P<0.05) 2. 1개월 투여 그룹의 경우, 혈관벽 두께는 세 군간에 유의한 차이를 보이는 것으로 나타났고, 각 군 간의 차이를 비교하였을 때 중국 홍삼군의 경우 다른 두 군에 비해 혈관벽두께 감소가 유의한 차이를 보였다.(P<0.05) 2개월 투여 그룹의 경우, 혈관벽 두께는 세 군간에 유의한 차이를 보이는 것으로 나타났고, 각 군 간의 차이를 비교하였을 때 중국 홍삼군의 경우 다른 두 군에 비해 혈관벽 두께 증가가 유의한 차이를 보였다.(P<0.05) 3개월 투여 그룹의 경우, 혈관벽 두께는 세 군간에 유의한 차이를 보이는 것으로 나타났고, 각군 간의 차이를 비교하였을 때 중국 홍삼군의 경우 한국 홍삼군에 비해 혈관벽 두께의 증가가 유의하였으며 대조군에 비해서는 혈관벽 두께 감소 경향을 나타내었으나 통계적 유의성은 없었다. 한국 홍삼군의 경우 두 군에 비해 혈관벽 두께의 감소가 유의하였다.(P<0.05) 3. 대동맥 조직 병리 검사 변화상 한국 홍삼군은 모두 대동맥 벽이 잘 유지되어 있고 단층 혈관 내피 세포가 잘 유지되어 있으나, 중국 홍삼의 경우 1개월, 2개월, 3개월 투여시 세포핵의 비후가 비교적 뚜렷하게 관찰되며 세포핵의 방향성(Orientation)과 극성(Polarity)의 소실이 특징적으로 관찰되었고 평활근 섬유가 갈라지거나 찢어진(Split or tearing) 양상을 관찰할 수 있었다. 이상으로, 홍삼 투여 시 혈압 강하 효과가 나타남을 알 수 있었고, 한국 홍삼이 중국 홍삼에 비해 혈압 하강 효과를 좀 더 지속시킬 가능성 및 대동맥 조직 병리 소견 상 혈관 보호 효과에 대한 추론을 할 수 있었다.

Keywords

References

  1. Kim, N. D. : Vasorelaxant effect of Ginseng and role of endothelium. J. Ginseng Res. 16(1), 78 (1992)
  2. Nam, K. Y., Sub, J. S., Chang, S. J., Jeon, B. H. and Park, H. K. : Vasorelaxiing effect by Protopanaxatriol and protopanaxadiol of Panax Ginseng in the pig coronary artery. J. Ginseng Res. 18(2), 95-102 (1994)
  3. Han, K., Shin, I. C., Choi, K. J., Yun, Y. P., Hong, J. T., Oh, K. W. : Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath. Nitric oxide. 12(3), 159-62 (2005) https://doi.org/10.1016/j.niox.2005.02.001
  4. Achike, F. I. and Kwan, C. Y. : Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Clin Exp Pharmacol Physiol. 30(9), 605-15 (2003) https://doi.org/10.1046/j.1440-1681.2003.03885.x
  5. Park, H. J., Rhee, M. H., Park, K. M., Nam, K. Y. and Park, K. H. : Effect of non-saponin fraction from Panax Ginseng on cGMP and thromboxane A2 in human platelet aggregation. Ethono Pharmacology. 49, 157-62 (1995) https://doi.org/10.1016/0378-8741(95)01317-2
  6. Nham, C. C. : The experimental studies on the influence of Ginseng to the atherosclerosis in rabbits. Kor. J. of Internal Medicine. 4(3), 49-54 (1961)
  7. Nakajima, S., Uchiyama, Y., Yoshida, K., Mizukawa, H. and Haruki, E. : The effects of genseng radix rubra on human vascular endothelial cells. Am J Cjin Med. 26(3-4), 365-73 (1998) https://doi.org/10.1142/S0192415X98000403
  8. Choi, Y. D., Xin, Z. C., Choi, H. K. : Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res. 10(1), 37-43 (1998) https://doi.org/10.1038/sj.ijir.3900300
  9. Han, K. H., Cohe, S. C., Kim, H. S., Sohn, D. W., Nam, K. Y., Oh, B. H., Lee, M. M., Park, Y. B., Choi, Y. S. : Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med. 26(2), 199-209 (1998) https://doi.org/10.1142/S0192415X98000257
  10. Von Sonntag. : The chemical basis of radiation of biology. Tylor and Francis, London. p. 31 (1987)
  11. Kawamura, M., Heinecke, J. W. and Chait, A. : Pathophysiological concentraions of glucose prompts oxidative modification of low density lipoprotein by a superoxidedependent pathway. J Clin Invest 94, 771-778 (1994) https://doi.org/10.1172/JCI117396
  12. Semenkovich, C. F. and Heinecke, J. W. : The mystery of diabetes and atherosclerosis. Time for a new plot. Diabetes 46, 327-334 (1997) https://doi.org/10.2337/diabetes.46.3.327
  13. Yamamoto. M., Uemura, T., Nkama, S., Uemyra M. and Kumagai, A. : Serum HDL-cholesterol increasing and fatty liver improving actions of Panax Ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man. A.J.of Chinese Medicine. 4, 96-101 (1983)
  14. Ikehara, M. Shibata, Y., Higashi, T., Sanada, S. and Shji, J. : Effect of Ginseng Saponins on cholesterol metabolism.III. Chem Parm Bull. 26(9), 284-5 (1978)
  15. Joo, C. N. : Biochemical studies on ginseng Saponons. Korean Biochem J. 13(1), 51-59 (1980)
  16. Deng, H. W., Guan, Y. Y. and Kwan, C. Y. : Effects of ginseng saponins on lipid peroxidation in liver and cardiac muscle homogenates. Biochem Arch 6, 359-365 (1990)
  17. Chen X. : Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol 23, 728-732 (1996) https://doi.org/10.1111/j.1440-1681.1996.tb01767.x
  18. Gillis, C. N. : Panax Ginseng pharmacology; a nitric oxide link? Biochem Pharmacol 54, 1-8 (1997) https://doi.org/10.1016/S0006-2952(97)00193-7
  19. Li, J., Huang, M., Teoh, H. and Man, R. Y. K. : Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Sciences 64, 53-62 (1999) https://doi.org/10.1016/S0024-3205(98)00533-5
  20. Pan, H,. Lin, F., Qiu, J., Huang, F., Chiu, T. and Zhang, Z. : Antioxidant action of certain simple phenolic compounds derived from Chinese herbs. Chin Med Sci J. 6, 52-55 (1991)
  21. Kim, S. S., Kim, J. D., Shin, M., S., Park, C. K., Park, H. M. and Yang, J. W. : The effect of Ginseng Product and Combined Exercise on blood lipids and body composition of obese women in their twenties. J. Ginseng Res. 26, 59 (2002) https://doi.org/10.5142/JGR.2002.26.2.059
  22. Kim, S. S., Kim, J. D., Shin, M., S., Park, C. K., Park, H. M. and Yang, J. W. : The effects on the blood lipid profiles and body fat by long term administration of Red ginseng products. J. Ginseng Res. 26, 67 (2002) https://doi.org/10.5142/JGR.2002.26.2.067
  23. 김희숙, 장석종, 전병화. : 신성고혈압백서에서 혈압에 미치는 고려홍삼사포닌과 비사포닌의 효과. J Ginseng Res. 23(2), 81-7 (1999)

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