The Korea Journal of Herbology (대한본초학회지)
- Volume 23 Issue 4
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- Pages.81-89
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
The Ethylacetate Extract of North Kangwhal(Ostericum koreanum) Attenuates the Inflammatory Responses in PMA/A23187-stimulated Mast Cells
북강활 에틸아세테이트분획의 비만세포에서의 염증반응 억제효과
- Seo, Un-Kyo (Department of Internal Medicine, Dongguk University Oriental Hospital) ;
- Lee, Ju-Il (Department of Internal Medicine, Dongguk University Oriental Hospital) ;
- Park, Jun-Hong (Bongwha Alpine Medicinal Plant Experiment Station) ;
- Park, Yong-Ki (Oriental Medicine Drug R&D Center and Oriental Medicine Research Institute, College of Oriental Medicine, Dongguk University)
- 서운교 (동국대학교 분당한방병원 내과) ;
- 이주일 (동국대학교 분당한방병원 내과) ;
- 박준홍 (봉화고랭지약초시험장) ;
- 박용기 (동국대학교 한의과대학 한방신약개발센터.한의학연구소)
- Published : 2008.12.30
Abstract
Objectives: In this study, the pharmacological effects of the ethylacetate extract of Ostericum koreanum(North Kangwhal; NK) on allergic inflammation were investigated in activated human mast cells. Methods: North Kangwhal was extracted with 80% methanol for 24 h, and then fractionated with ethylacetate(NK-EtOAc extract). HMC-1 cells, an human mast line, were pre-incubated with different concentrations of NK-EtOAc extract for 30 min, and then stimulated with PMA(50 nM/ml) and A23187(