Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Experimental study on the periodontal regenerative capacity of moldable synthetic peptide domain gel in degree III furcation defect of beagles

성견의 3급 이개부 병변에서 성형성 합성 펩타이드 젤의 치주재생 능력에 관한 실험적 연구

  • Kim, Jeong-Beom (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Park, Yoon-Jeong (Department of Head and Neck Reconstruction, School of Dentistry, Seoul National University) ;
  • Lee, Sang-Cheol (NIBEC Corp.) ;
  • Kim, Tae-Il (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Seol, Yang-Jo (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Lee, Yong-Moo (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Gu, Young (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Rhyu, In-Chul (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Han, Soo-Boo (Department of Periodontology, School of Dentistry, Seoul National University) ;
  • Chung, Chong-Pyoung (Department of Periodontology, School of Dentistry, Seoul National University)
  • 김정범 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 박윤정 (서울대학교 치의학전문대학원 두개악안면재건학교실) ;
  • 이상철 ((주) 나이벡) ;
  • 김태일 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 설양조 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 이용무 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 구영 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 류인철 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 한수부 (서울대학교 치의학전문대학원 치주과학교실) ;
  • 정종평 (서울대학교 치의학전문대학원 치주과학교실)
  • Published : 2008.12.31
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Abstract

Purpose: Osteopontin is one of the major non-collagenous protein of hard tissue. Use of peptide domain of biologically active protein has some advantages. The objective of this experimental study is evaluation of periodontal regenerative potency of synthetic peptide gel which containing collagen binding domain of osteopontin in the degree III periodontal defect of beagle dogs. Material and Methods: Experimental degree III furcation defect was made in the mandibular third and fourth premolar of beagles. Regenerative material was applied during flap operation. 8 weeks after regenerative surgery, all animals were sacrificed and histomorphometric measurement was performed to calculate the linear percentage of the new cementum formation and the volume percentage of new bone formation. Result: The linear percent of new cementum formation was 41.6% at control group and 67.1% at test group and there was statistically significant difference. The volume percent of new bone formation was 52.1% at control group and 58.9% at test group. Conclusion: As the results of present experiment, synthetic peptide gel containing collagen binding domain of osteopontin significantly increase new bone and cementum formation in the degree III furcation defect of canine mandible.

Keywords

References

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