Investigative Magnetic Resonance Imaging
- 제12권2호
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- Pages.115-122
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- 2008
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- 2384-1095(pISSN)
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- 2384-1109(eISSN)
Superparamagnetic Iron Oxide-Enhanced MRI를 이용한 간섬유화의 평가: 영상의학적 비침습적 간섬유화 지표가 AST/혈소판 비와 상관 관계가 있는가?
Evaluation of Fibrosis in Liver Cirrhosis by Superparamagnetic Iron Oxide (SPIO)-Enhanced MR Imaging: Does the Radiological Non-Invasive Fibrosis Index Correlate with the Laboratory Non-Invasive Fibrosis Index?
- 김신기 (고려대학교 구로병원 영상의학과) ;
- 이창희 (고려대학교 구로병원 영상의학과) ;
- 김경아 (고려대학교 구로병원 영상의학과) ;
-
최재웅
(고려대학교 구로병원 영상의학과) ;
- 이종미 (고려대학교 구로병원 영상의학과) ;
- 박철민 (고려대학교 구로병원 영상의학과)
- Kim, Shin-Kee (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
- Lee, Chang-Hee (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
- Kim, Kyeong-Ah (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
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Choi, Jae-Woong
(Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
- Lee, Jong-Mee (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
- Park, Cheol-Min (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
- 발행 : 2008.12.30
초록
목적: SPIO-enhanced MRI상에서 얻은 radiological non-invasive hepatic fibrosis index (RNHFI)와 AST/혈소판 비(AST to platelet ratio index, APRI)간의 상관관계를 알아보고자 하였다. 대상 및 방법: 5년동안 SPIO-enhanced MRI를 시행받은 환자들을 대상으로 하였다. 환자들을 간경변 집단과 비(非)간경변 집단으로 분류했다. PACS를 이용, 각 환자의 SPIO-enhanced MRI에서 RNHFI (간실질 신호강도 표준편차의 평균(SD), 잡음교정 변이계수(CV))를 산출했고, 각 환자의 실험실 검사 결과를 이용, APRI를 산출했다. Student's t-test를 이용하여 두 집단간의 RNHFI와 APRI의 차이를 비교했다. 각 집단에서, RNHFI와 APRI간의 이변량 상관분석을 시행했다. 결과: 간경변 집단에서, SD, CV의 평균은 각각
Purpose : To evaluate the correlation between the radiological non-invasive hepatic fibrosis index (RNHFI), as determined by SPIO-enhanced MRI, and the laboratory non-invasive hepatic fibrosis index. Materials and Methods : Patients (99 total: 61 men and 38 women; mean age: 58 years) who underwent SPIO-enhanced MRI (1.5T) during 5 years included. These patients were subdivided into a liver cirrhosis group (LCG) and a non-liver cirrhosis group (non-LCG). Using PACS view, we measured the RNHFI (mean standard deviation of hepatic signal intensity (SD), noise-corrected coefficient of variation (CV)) of three ROIs in the liver parenchyma by SPIO-enhanced MRI. The laboratory non-invasive hepatic fibrosis index (AST-platelet ratio index (APRI)) of all patients was calculated from the laboratory data. We compared the RNHFI and APRI of LCG with those of non-LC group using Student's t-test. A bivariate correlation was performed to investigate the relationship between the RNHFI and APRI in the LCG. Results : For the LCG, mean values of SD and CV by SPIO-enhanced MRI were