Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Proteasome Inhibition Activity of Hericium erinaceum

노루궁뎅이 버섯의 Proteasome 저해 작용

  • Lee, Han-Na (School of Biotechnology, Yeungnam University) ;
  • Kim, Yu-Jin (School of Biotechnology, Yeungnam University) ;
  • Shim, Sang-Hee (School of Biotechnology, Yeungnam University)
  • 이한나 (영남대학교 생명공학부) ;
  • 김유진 (영남대학교 생명공학부) ;
  • 심상희 (영남대학교 생명공학부)
  • Published : 2008.12.31
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Abstract

Recently proteasome inhibitors have been emerged as potential anticancer agents. In a continuous study on exploring proteasome inhibitors from natural products, fruiting body of Hericium erinaceum was investigated. The MeOH extracts of the fruiting body of Hericium erinaceum was fractionated with several solvents and the fractions were evaluated on the activity to screen the proteasome inhibitors. The n-Hexane and CHCl3 frs. showed potent activity, of which chemical investigations led to ergosterol peroxide (1), hericenones C (2) and D (3). Their structures were determined by spectroscopic methods such as $^1H$-NMR, $^{13}C$-NMR, and FABMS spectra.

Keywords

References

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