Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Flavonol Glycosides with Antioxidant Activity from the Aerial Parts of Epimedium koreanum Nakai

  • Kim, Eun-Sil (College of Natural Sciences, DukSung Women's University) ;
  • Kim, Mi-Kyung (College of Natural Sciences, DukSung Women's University) ;
  • Kang, Hyun-Kyu (College of Life Sciences and Biotechnology, Korea University) ;
  • Park, Young-In (College of Life Sciences and Biotechnology, Korea University) ;
  • Dong, Mi-Sook (College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Chung, Ha-Sook (College of Natural Sciences, DukSung Women's University)
  • Published : 2008.12.31
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Abstract

The aerial parts of Epimedium koreanum Nakai have been used to stimulate hormone secretion in treating impotence. Ten flavonol glycosides, 3,4,5-trihydroxy-8-prenylflavone 7-O-[${\beta}$-D-glucopyranosyl($1{\rightarrow}2$)-${\beta}$-D-glucopyranoside] (1), hyperoside (2), icarisid II (3), 2"-O-Rhamnosylicarisid II (4), epimedin A (5), epimedin B (6), epimedin C (7), icariin (8), hexandraside E (9), and epimedoside A (10) were isolated from the an ethylacetate soluble extracts of the aerial parts of Epimedium koreanum Nakai through activity-monitord fractionation and isolation method. The structures of compounds 1 - 10 were elucidated by high resolution fast atom bombardment mass spectrometry and two dimentional nuclear magnetic resonance spectroscopy analysis. Compounds 1 and 4 showed potent antioxidant activity, with $IC_{50}$ values of 19.7 and 11.5 ${\mu}g$/mL and 88.2 and 90.5 ${\mu}M$, respectively.

Keywords

References

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