Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Ulmi Cortex Prevents Cisplatin-Induced Apoptosis in Mice

시스플라틴에 의한 세포고사에서 유근피(楡根皮)의 효과

  • Moon, Mi-Hyun (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Ji-Young (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Seon-Ah (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Yong-Jeen (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Ko, Seok-Jae (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Goo (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 문미현 (원광대학교 한의과대학 내과학교실) ;
  • 전지영 (원광대학교 한의과대학 내과학교실) ;
  • 이선아 (원광대학교 한의과대학 내과학교실) ;
  • 신용진 (원광대학교 한의과대학 내과학교실) ;
  • 고석재 (원광대학교 한의과대학 내과학교실) ;
  • 문구 (원광대학교 한의과대학 내과학교실)
  • Published : 2008.12.30
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Abstract

Objectives : The purpose of this study is to investigate the effect of Ulmi Cortex(UC) on the cisplatin-induced cell death. Materials and Methods : I examined several kinds of cell populations such as $CD4^+$ T cells, $CD8^+$ T cells, macrophages and dendritic cells in spleen. Result : When cisplatin was injected to mice, UC recovered total number of cells in spleen and also the number of T cells, macrophages and dendritic cells. UC also effected the activation of $CD4^+$ and $CD8^+$ T cells such as $CD25^+$, $CD69^+$ cells. To further investigate the effect of UC on the cisplatin-induced cell death, I examined the death of splenocyte and total T cells. UC inhibited cisplatin-induced cell death. Conclusion : Taken together, my results suggest that UC may be a beneficial oriental medicine for side effects during anti-tumor therapy.

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