Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Protective Effects of Sasa borealis Bamboo Browse Extract on Acetaminophen-induced Liver Damage in Mouse Model

Acetaminophen 유도 간 손상에 대한 조릿대 애엽 추출물의 보호 효과

  • Jang, Seon-Il (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Yun, Young-Gab (Department of Oriental medical prescription, Wonkwang University) ;
  • Park, Kwang-Hyun (Department of Biochemistry and Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Xie, Guanghua (Department of General Surgery, Affiliated Hospital of Yanbian University College of Medicine) ;
  • Kwon, Tae-Oh (Medicinal Resources Research Institute, Wonkwang University)
  • 장선일 (전주대학교 대체의학대학 대체건강관리학부) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실) ;
  • 박광현 (전북대학교 의학전문대학원 생화학교실) ;
  • 설광화 (중국 연변대학교 의과대학) ;
  • 권태오 (원광대학교 의약자원연구소)
  • Published : 2008.12.30
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Abstract

Acetaminophen (N-acety1-p-aminophenol, paracetamol) is widely used as an over-the-counter analgesic and antipyretic drug. Intake of a over dose of acetaminophen may result in severe hepatic necrosis. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of acetaminophen and the possible protective effects of administration (50-200 mg/kg body weight) of SB-Ex on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of SB-Ex on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase (${\sigma}$-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. Acetaminophen caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were general statistically significant losses in the activities of SOD, catalase, ${\sigma}$-ALA-D, and GPx and an increase in TBARS in the liver of acetaminophen-treated group compared with the control group. However, SB-Ex was able to counteract these effects. These results suggest that SB-Ex can act as hepatoprotectives against acetaminophen toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.

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