대한한의학방제학회지 (Herbal Formula Science)
- 제16권2호
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- Pages.163-169
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- 2008
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
혈관질환 억제 효능이 있는 BDR-29의 백서 신장 독성연구
Study on Kidney Toxicity of BDR-29 for Treatment Vascular Diseases in Rats
- 김은주 (원광대학교 한의학전문대학원 한약자원개발학) ;
-
강대길
(원광대학교 한의학전문대학원 한약자원개발학)
;
- 이안숙 (원광대학교 한의학전문대학원 한약자원개발학) ;
-
최덕호
(원광대학교 한의학전문대학원 한약자원개발학)
;
- 조국현 (원광대학교 한의학전문대학원 한약자원개발학) ;
-
김성연
(원광대학교 약학대학교 약학과)
;
-
이호섭
(원광대학교 한의학전문대학원 한약자원개발학)
- Kim, Eun-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
-
Kang, Dae-Gill
(Professional Graduate School of Oriental Medicine, Wonkwang University)
;
- Lee, An-Sook (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
-
Choi, Deok-Ho
(Professional Graduate School of Oriental Medicine, Wonkwang University)
;
- Cho, Kuk-Hyun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
-
Kim, Sung-Yun
(Dept. of Pharmacy, College of Pharmacy, Wonkwang University)
;
-
Lee, Ho-Sub
(Professional Graduate School of Oriental Medicine, Wonkwang University)
- 발행 : 2008.12.30
초록
The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.