Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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The Association of Cardiovascular Risk Factors with Nonalcoholic Fatty Liver Disease in Health Checkup Examinees

일부 종합검진 수검자 중 비알코올성 지방간과 심혈관질환 위험요인과의 관련성

  • Yu, Jae-Hee (Graduate School of Public Health, The Catholic University of Korea) ;
  • Lee, kang-Sook (Department of Prevention Medicine & Catholic Industrial Medical Center, The Catholic University of Korea) ;
  • Lee, Seon-Young (Department of Prevention Medicine & Catholic Industrial Medical Center, The Catholic University of Korea) ;
  • Hong, A-Rum (Department of Prevention Medicine & Catholic Industrial Medical Center, The Catholic University of Korea) ;
  • Park, Yong-Sang (Health Promotion Center, St Mary's Hospital The Catholic University of Korea)
  • 유재희 (가톨릭대학교 보건대학원) ;
  • 이강숙 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터) ;
  • 이선영 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터) ;
  • 홍아름 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터) ;
  • 박용상 (여의도성모병원 건강증진센터)
  • Published : 2008.11.30
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Abstract

Objectives: The purpose of this study was to evaluate the relationship of nonalcoholic fatty liver and cardiovascular risk factors. Methods: This study was conducted to investigate the association of nonalcoholic fatty liver and cardiovascular risk factors for adult men (n=2976) and women (n=2442) who were over 19 years old, after excluding the HBsAg(+) or anti-HCV(+) patients and the men and women with increased alcohol intake (men: 40g/week, women: 20g/week). Results: Compared with the normal liver subjects, the nonalcoholic fatty liver subjects showed a significantly increased frequency of abnormal systolic blood pressure (${geq}120mmHg$), fasting blood sugar (${\geq}100mg/dL$), total cholesterol ($({\geq}200 mg/dL$), triglyceride ($({\geq}150mg/dL$), high density lipoprotein cholesterol (<40 mg/dL), low density lipoprotein cholesterol ($({\geq}130g\; m/dL$) and abdominal obesity in men, and all these measures were significantly increased in the women except for abnormal HDL cholesterol. After adjusting for the body mass index, age, smoking, exercise and a nonalcoholic liver, the odds ratios of an abnormal waist hip ratio were 1.35(95% Confidence Interval=1.05-4.72) in the mild fatty liver, 1.61 (1.19-2.18) in the moderate fatty liver, 2.77(1.57-4.92) in the severe fatty liver compared with a normal liver. The adjusted odds ratios for abnormal fasting blood sugar were 1.26(1.03-1.53) in the mild fatty liver, 1.62(1.27-2.06) in the moderate fatty Iiver and 1.77(1.12-2.78) in the severe fatty liver. The adjusted odds ratios for abnormal triglyceride were 1.38(1.11-1.72) in the mild fatty liver, 1.73(0.33-2.24) in the moderate fatty liver and 1.91 (1.17-3.10) in the severe fatty liver of men. Adjusted odds ratios for abnormal triglyceride were 1.50(1.04-2.15) in mild, 1.71(1.07-2.68) in moderate, 1.81(0.69-4.38) in severe fatty liver of women. Conclusions: The nonalcoholic fatty liver subjects had more cardiovascular risk factors compared with the normal liver subjects. Thus, prevention and treatment of the nonalcoholic fatty liver is necessary by lifestyle modifications such as restriction of alcohol intake, no smoking, exercise and adequate eating habits.

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