Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Activation of Adenosine A2A Receptor Impairs Memory Acquisition but not Consolidation or Retrieval Phases

  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University) ;
  • Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
  • Published : 2008.12.31
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Abstract

Several lines of evidence indicate that adenosine $A_{2A}$ agonist disrupts spatial working memory. However, it is unclear which stages of learning and memory are affected by the stimulation of adenosine $A_{2A}$ receptor. To clarify these points, we employed CV-1808 as adenosine $A_{2A}$ agonist and investigated its effects on acquisition, consolidation, and retrieval phases of learning and memory using passive avoidance and the Morris water maze tasks. During the acquisition phase, CV-1808 (2-phenylaminoadenosine, 1 and 2 mg/kg, i.p.) decreased the latency time in passive avoidance task and the mean savings in the Morris water maze task, respectively. During the consolidation and retrieval phase tests, CV-1808 did not exhibited any effects on latency time in passive avoidance task and the mean savings in the Morris water maze task. These results suggest that CV-1808 as an adenosine $A_{2A}$ agonist impairs memory acquisition but not consolidation or retrieval.

Keywords

References

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