Bulletin of the Korean Chemical Society

  • 제29권8호
  • /
  • Pages.1472-1478
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  • 2008
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

  • Park, Hyeong-Beom (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Jung, Myung-Ho (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Cho, Jung-Hyuck (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Biomaterials Research Center, Korea Institute of Science and Technology)
  • 발행 : 2008.08.20
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초록

The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.

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참고문헌

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피인용 문헌

  1. ChemInform Abstract: Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part 2. vol.40, pp.6, 2009, https://doi.org/10.1002/chin.200906209