Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Preparation and Characterization of Vesicles Using Octasubstituted Cyclotetraphosphazene

  • Shin, Young-Jae (Department of Electrical Engineering and Computer Science, Texas A&M University) ;
  • Park, Chul-Soon (Department of Chemistry, Chungbuk National University) ;
  • Lee, Chun-Il (Hanbul Cosmetics) ;
  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University)
  • Published : 2008.10.20
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Abstract

A cyclotetraphosphazene derivative with eight chains was synthesized from octachlorocyclotetraphosphazene. The vesicles were prepared using the cyclotetraphosphazene derivative and cholesterol. The resulting vesicles were characterized by TEM and measurements of their encapsulation efficiency. The stability of the vesicles was enhanced with the addition of dihexadecylphosphate. The size and the encapsulation efficiency of the vesicles changed according to the amount of cholesterol added. The size and the encapsulation efficiency of the vesicle were lowest when the mole ratio (cholesterol: the cyclophosphazene derivative) was 0.9.

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