Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Concise Total Synthesis of Biologically Interesting Prenylated Chalcone Natural Products: 4'-O-Methylxanthohumol, Xanthohumol E, and Sericone

  • Lee, Yong-Rok (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Li, Xin (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Lee, Seung-Woo (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Yong, Chul-Soon (College of Pharmacy, Yeungnam University) ;
  • Hwang, Ma-Ro (College of Pharmacy, Yeungnam University) ;
  • Lyoo, Won-Seok (School of Textiles, Yeungnam University)
  • Published : 2008.06.20
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Abstract

A new and efficient synthetic approach is reported for biologically interesting prenylated chalcones, 4'-Omethylxanthohumol (3), xanthohumol E (4), and sericone (5) from 2,4,6-trihydroxyacetophenone. The strategies involve the introduction of a prenyl group onto an aryl ring, benzopyran formation, and basecatalyzed aldol reactions.

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