Bulletin of the Korean Chemical Society

  • 제29권6호
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  • Pages.1205-1210
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  • 2008
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Concise Total Synthesis of Biologically Interesting Prenylated Chalcone Natural Products: 4'-O-Methylxanthohumol, Xanthohumol E, and Sericone

  • Lee, Yong-Rok (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Li, Xin (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Lee, Seung-Woo (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Yong, Chul-Soon (College of Pharmacy, Yeungnam University) ;
  • Hwang, Ma-Ro (College of Pharmacy, Yeungnam University) ;
  • Lyoo, Won-Seok (School of Textiles, Yeungnam University)
  • 발행 : 2008.06.20
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초록

A new and efficient synthetic approach is reported for biologically interesting prenylated chalcones, 4'-Omethylxanthohumol (3), xanthohumol E (4), and sericone (5) from 2,4,6-trihydroxyacetophenone. The strategies involve the introduction of a prenyl group onto an aryl ring, benzopyran formation, and basecatalyzed aldol reactions.

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  1. Facile Synthesis of Licochalcone C vol.35, pp.7, 2014, https://doi.org/10.5012/bkcs.2014.35.7.1996
  2. vol.78, pp.11, 2015, https://doi.org/10.1021/acs.jnatprod.5b00721
  3. Species vol.79, pp.9, 2016, https://doi.org/10.1021/acs.jnatprod.6b00224
  4. ChemInform Abstract: Concise Total Synthesis of Biologically Interesting Prenylated Chalcone Natural Products: 4′-O-Methylxanthohumol (VIII), Xanthohumol E (XII), and Sericone (XIII). vol.39, pp.43, 2008, https://doi.org/10.1002/chin.200843208
  5. Anti-Invasive and Anti-Angiogenic Effects of Xanthohumol and Its Synthetic Derivatives vol.17, pp.4, 2008, https://doi.org/10.4062/biomolther.2009.17.4.422
  6. New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray vol.26, pp.3, 2008, https://doi.org/10.3390/molecules26030688