Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents

  • Kim, Kyung-Ran (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Park, Ah-Young (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Lee, Hyung-Rock (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Kang, Jin-Ah (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Kim, Won-Hee (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Chun, Pu-Soon (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Bae, Jang-Ho (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University) ;
  • Jeong, Lak-Shin (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Moon, Hyung-Ryong (Laboratory of Medicinal Chemistry, College of Pharmacy and Research Institute for Drug Development, Pusan National University)
  • Published : 2008.10.20
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Abstract

Novel bicyclo[3.1.0]hexanyl purine nucleoside analogues were synthesized as potential antiherpetic agents via a bicyclo[3.1.0]hexanol (${\pm}$)-8, which was prepared using a highly efficient carbenoid cycloaddition reaction. A highly diastereoselective reduction of ketone and a Mitsunobu reaction for the condensation of glycosyl donor (${\pm}$)-12 with 6-chloropurine were employed.

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References

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