The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
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The effects of ipriflavone on the periodontal reorganization following experimental tooth movement in the rat

Ipriflavone 투여가 백서의 실험적 치아이동 후 치주조직의 재형성에 미치는 영향

  • Min, Ji-Hyun (Department of Orthodontics, School of Dentistry, Chonnam National University) ;
  • Cho, Jin-Hyoung (Department of Orthodontics, 2nd Stage of Brain Korea 21, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Lee, Ki-Heon (Department of Orthodontics, 2nd Stage of Brain Korea 21, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Hwang, Hyeon-Shik (Department of Orthodontics, 2nd Stage of Brain Korea 21, School of Dentistry, Dental Science Research Institute, Chonnam National University)
  • 민지현 (전남대학교 치과대학 교정학교실) ;
  • 조진형 (전남대학교, 치의학연구소, 2단계 BK21 사업단, 치과대학 교정학교실) ;
  • 이기헌 (전남대학교, 치의학연구소, 2단계 BK21 사업단, 치과대학 교정학교실) ;
  • 황현식 (전남대학교, 치의학연구소, 2단계 BK21 사업단, 치과대학 교정학교실)
  • Published : 2008.10.30
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Abstract

Objective: The purpose of this study was to examine the effect of ipriflavone on periodontal reorganization and prevention of relapse following tooth movement. Methods: Orthodontic rubber bands were inserted between the first and second maxillary molars of 27 white male rats for 3 weeks for experimental tooth movement. From one day before the removal of orthodontic rubber band, ipriflavone was administered 50 or 400 mg/kg daily in each experimental group whereas carboxymethyl cellulose solution was administered in the control group. They were sacrificed at the 5, 10, and 15th day from the day of removal of orthodontic rubber bands. The amount of relapse was evaluated by measuring the interdental space, and the extent of periodontal reorganization was compared through histological examination. Results: In case of ipriflavone administration, the amount and velocity of relapse was less and slower compared to the control group. In addition, the ipriflavone group showed more rapid periodontal reorganization compared to the control group. Conclusions: The results of the present study suggest that ipriflavone administration can be used effectively in the prevention of relapse following orthodontic tooth movement through the acceleration of periodontal reorganization.

본 연구는 치아이동 후 ipriflavone 투여가 치주조직의 재형성, 나아가 치아회귀 억제에 미치는 영향을 알아보기 위하여 시행되었다 웅성 백서 72마리를 대상으로 상악 좌우측 제1, 2구치 사이에 교정용 고무밴드를 끼워 제1, 2구치를 3주간 이동시킨 다음, 교정용 고무밴드 제거 1일 전부터 매일 체중 kg당 50 mg 또는 400 mg의 ipriflavone을 투여한 실험군과 ipriflavone을 투여하지 않은 대조군으로 구분하였다. 교정용 고무밴드를 제거함으로써 회귀가 나타나기 시작한 날로부터 5일 간격으로 15일까지 각각 실험동물을 희생시켜가며 치아회귀 거리를 계측하는 한편 치주조직 재형성 소견을 관찰하였다. Ipriflavone을 투여하고 치아회귀를 관찰한 결과 용량에 관계없이 대조군에 비하여 적은 양의 회귀를 나타내었으며 시간 간격에 따른 치아회귀를 관찰한 결과 대부분의 회귀가 5일째 나타난 대조군과 달리, 늦게 그리고 점진적으로 나타나는 양상을 보였다. Iprinavone을 투여하고 조직소견을 관찰한 결과 대조군에 비하여 치조골연이 매끄러운 양상을 보였으며 시간 간격에 따른 조직소견을 관찰한 결과 대조군에 비하여 치주인대 재배열이 빠르게 나타나는 양상을 보였다. 이상의 결과는 ipriflavone의 투여가 치주조직의 재형성을 통하여 회귀를 억제함으로 교정적 치아이동 후 보정에 도움이 될 수 있음을 시사하였다.

Keywords

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