Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Anti-diabetic activity of Thespesia lampas Dalz & Gibs on alloxan induced rats

  • Jayakar, B (Vinayaka Mission's of pharmacy, Vinayaka Missions University) ;
  • Sangameswaran, B (Vinayaka Mission's of pharmacy, Vinayaka Missions University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Anti-diabetic effect was observed with Thespesia lampas Dalz & Gibs (Family: Malvaceae) when given as a root extract in normal as well as alloxan induced diabetic rats. The effects, however, were more pronounced in diabetic animals in which administration of plant extract for 15 days after alloxan induced diabetes, significantly reduced blood glucose levels. After alloxan induced diabetes it was observed that both standard drug (glibenclamide) and aqueous extract of Thespesia lampas were significantly superior to control in reducing blood sugar on long term treatment (15 days). The aqueous extract of T. lampas (300 and 600 mg/kg) reduced the blood glucose levels from $349.2{\pm}7.2$ to $120.7{\pm}4.6$ and $346.3{\pm}3.4$ to $101.8{\pm}6.3$, respectively. The data suggested that T. lampas could be of beneficial in diabetes mellitus in controlling blood sugar. The present investigation established pharmacological evidence to support the folklore claim as an anti-diabetic.

Keywords

References

  1. Aiman R. (1970) Recent research in indigenous antidiabetic medicinal plants, An Overall Assessment. Indian J. physiol. Pharmacol. 14, 65-75
  2. Atta-Ur-Rhemann, Khurshid Zaman. (1989) Medicinal plants with hypoglycemic activity. J. Ethnopharmacol. 26, 1-55 https://doi.org/10.1016/0378-8741(89)90112-8
  3. Babu V, Gangagadevi T, Subramaniam A. (2003) Anti diabetic activity of ethanolic extract of Cassia kleinii leaf in streptozotocin-induced Diabetic rats and isolation of an active fraction and toxicity evaluation of the extract. Indian J. Pharmacol. 35, 290-296
  4. Bennet PH. (1998) Joslin's. Diabetes Mellitus, Kahan RC, Weir GC, eds Baltimore, international publication Waverley p 193-200
  5. Ghosh M. (1994) Fundamentals of Experimental pharmacology 2nd edition p 158-159, Scientific book agency, Kolkatta
  6. Ivorra MD, Paya M, Villar A. (1989) A review of Natural Products and Plants as Potent antidiabetic drugs. J. Ethnopharmacol. 27, 243-275 https://doi.org/10.1016/0378-8741(89)90001-9
  7. Khan CR, Shechter Y. (1991) Insulin oral hypoglycaemic agents, and the pharmacology of endocrine pancreas. In: Goodman & Gilman's. The Pharmacological Basis of Therapeutics 8th edition p 1463-1495, Pergamon Press, New York
  8. Moller DE. (2001) New drug targets for type 2 diabetes and metabolic syndrome. Nature 414, 821-827 https://doi.org/10.1038/414821a
  9. Nagarajan S, Jain HC, Aulakh GS. (1987) Indigenous plants used in the control of Diabetes. (Publication and Information directorate), C.S.I.R, New Delhi, 588-589
  10. Pullock K, Mukarjee. (2002) Pharmacological Evaluation of Herbal Drugs, Quality control herbal drugs 1 st edition, p 527, Business horizons New Delhi
  11. Sheweita SA, Newair AA, Mansour HA, Yousef M. (2002) Effect of some hypoglycemic herbs on the activity of phase I and phase II drug-metabolizing enzymes in alloxan-induced diabetic rats, Toxicity 174, 131-139 https://doi.org/10.1016/S0300-483X(02)00048-3
  12. Woodson RF. (1987) Statistical Methods for the Analysis of Biomedical Data-Probability and Mathaematical Statistical. Wiley, Chichester 315-316

Cited by

  1. Pharmacognostic standardization of stems of Thespesia lampas (Cav.) Dalz & Gibs vol.2, pp.5, 2012, https://doi.org/10.1016/S2221-1691(12)60056-2