Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antibacterial, cytotoxic and neuropharmacological activities of Cerbera odollam seeds

  • Ahmed, F (Pharmacy Discipline, Khulna University) ;
  • Amin, R (Biotechnology and Genetic Engineering Discipline, Khulna University) ;
  • Shahid, IZ (Pharmacy Discipline, Khulna University) ;
  • Sobhani, MME (Biotechnology and Genetic Engineering Discipline, Khulna University)
  • Published : 2008.12.31
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Abstract

The MeOH extract of seeds of Cerbera odollam Gaertn. (Apocynaceae) was screened for its antibacterial, cytotoxic and neuropharmacological activities. The extract showed moderate anti-bacterial activity against Salmonella typhi, Streptococcus saprophyticus, and Streptococcus pyogenes. It exhibited high level cytotoxicity against brine shrimp ($LC_{50}$: $3\;{\mu}g/ml$). The extract potentiated pentobarbital induced sleeping time in mice which was further supported by the exploratory behavior test at dose of 25 mg/kg. The overall results tend to suggest the antibacterial, cytotoxic and CNS depressant activities of the extract.

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References

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