대한약침학회지 (Journal of Pharmacopuncture)

  • 제11권4호
  • /
  • Pages.5-14
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  • 2008
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  • 2093-6966(pISSN)
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  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
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활락탕(活絡湯)의 cDNA Microarray를 이용한 유전자 발현에 미치는 영향

Genes expression by using cDNA Microarray in Whallak-tang

  • 신철경 (동의대학교 울산한방병원 한방내과) ;
  • 이채우 (동의대학교 한의과대학 침구경혈학교실) ;
  • 유선애 (동의대학교 한의과대학 소아과학교실) ;
  • 윤현민 (동의대학교 한의과대학 침구경혈학교실) ;
  • 장경전 (동의대학교 한의과대학 침구경혈학교실) ;
  • 송춘호 (동의대학교 한의과대학 침구경혈학교실) ;
  • 안창범 (동의대학교 한의과대학 침구경혈학교실) ;
  • 김철홍 (동의대학교 한의과대학 침구경혈학교실)
  • Sin, Cheol-Kyung (Department of Oriental Internal Medicine, Ulsan Oriental Medical Hospital, Dongeui University) ;
  • Lee, Chae-Woo (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Yoo, Sun-Ae (Department of Pediatrics, College of Oriental Medicine, Dongeui University) ;
  • Youn, Hyoun-Min (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Jang, Kyung-Jeon (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Ahn, Chang-Beohm (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Kim, Cheol-Hong (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University)
  • 발행 : 2008.12.30
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초록

Objective This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-1). Results The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in $200{\sim}300%$ range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in $0{\sim}33%$ range. Conclusion These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.

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참고문헌

  1. 동의대학교 한의과대학. 동의대학교 한방병원 처방집. 부산. 2001:441
  2. 임정은, 송호섭, 권순정, 이성노, 강미숙, 변임정, 황현서, 김기현. 鍼灸治療와 活絡湯투여가 급성요통 및 간기능에 미치는 영향에 관한 임상적 고찰. 대한침구학회지. 2001;18(5):43-9
  3. 申鉉大外. 東醫再活醫學科學. 서울:書苑堂. 1995:95-102
  4. 鄭錫熙 外. 痺證의 分類와 治療에 對한 考察. 東醫物理療法科學會誌. 1992;2(1):181-90
  5. 方廣. 丹溪心法附餘. 서울:大星文化社. 1993:188-91
  6. 李 梴. 國譯編註醫學入門. IV 卷. 서울:南山堂. 1989:193-212, 626-39
  7. 上海中醫學院編. 內科學(上). 上海:上海科學技術出版社.1983:234-8
  8. 王風岐 外. 炎症的中醫辨證. 北京:中醫藥學技術出版社. 1990:434~40
  9. 박종훈. DNA Chip. 대한내분비학회지. 2000;15(4):17-23
  10. 申炳熙, 李鍾秀, 申鉉大. 桂枝芍藥知母湯이 제 II 형 Collagen유발 관절염의 항체에 미치는 영향. 동의물리요법과학회지. 1994;4(1):121-33
  11. 정수현. 三痺湯이 Collagen으로 유발된 관절염에 미치는 영향. 세명대학교대학원. 2000
  12. 權純貞. 活絡湯이 Adjuvant 유발 관절염의 부종 및 혈액에 미치는 영향. 경원대학교대학원. 2002
  13. 辛民敎. 臨床本草學. 서울:永林社. 1991:222, 300, 453-5, 467, 504, 668-9
  14. 李尙仁. 本草學. 서울:修書院. 1981:428-9, 101-2, 231, 410, 532-3
  15. Butterfield JH, Weiler D, Dewald G, Gleich GJ. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leu-kemia Res 12. 1988:345-55 https://doi.org/10.1016/0145-2126(88)90050-1
  16. 王琦. 素問今釋. 貴州:貴州人民出版社. 1981:206-7
  17. 李京燮 外. 東醫心系內科學. 下卷. 서울:書苑堂. 1995:117-46
  18. 王浴生. 中藥藥理與應用. 北京:人民衛生出版社. 1983:339-44, 424-34
  19. Higuti T, Tsurumi C, Osaka F, Kawamura Y, Tsujita H, Yosh ihara Y, Tani I, Tanaka K, Ichihara A. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mito chondria. Biochem. Biophys. Res. Commun. 1991;178:1014-20 https://doi.org/10.1016/0006-291X(91)90993-H
  20. Bosetti F, Yu G, Zucchi R, Ronca-Testoni S, Solaini G. Myocardial ischemic preconditioning and mitochondrial F1F0-ATPase activity. Mol Cell Biochem. 2000 Dec;215(1-2):31-7 https://doi.org/10.1023/A:1026558922596
  21. Hovanessian A G, Laurent A G, Chebath J, Galabru J, Robert N, Svab J. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J. 6. 1987:1273-80
  22. Marie I, Galabru J, Svab J, Hovanessian A G. Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase. Biochem. Biophys. Res. Commun. 1989;160:580-7 https://doi.org/10.1016/0006-291X(89)92472-8
  23. Marie I, Hovanessian A G. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. J. Biol. Chem. 1992;267:9933-9
  24. Deblandre G A, Marinx O P, Evans S S, Majjaj S, Leo O, Caput D, Huez G A, Wathelet M G. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 1995;270:23860-6 https://doi.org/10.1074/jbc.270.40.23860
  25. Kim YD, Sohn NW, Kang C, Soh Y. DNA array reveals altered gene expression in response to focal cerebral ischemia. Brain Res Bull. 2002;Sep,15;58(5):491-8 https://doi.org/10.1016/S0361-9230(02)00823-7
  26. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, W atanabe K, Tanaka T. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implicati ons for human disorders. Genomics. 2001;77:65-70 https://doi.org/10.1006/geno.2001.6622
  27. Ou J-H, Yen T S B, Wang Y-F, Kam W K, Rutter W J, Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. Nucleic Acids Res. 1987;15:891 9-34, Note: Erratum:Nucleic Acids Res. 1988;16:4196 https://doi.org/10.1093/nar/16.9.4196
  28. Urnov FD. A feel for the template:zinc finger protein transcription factors and chromatin. Biochem Cell Biol. 2002;80(3):321-33 https://doi.org/10.1139/o02-084
  29. Pahl P, M B, Hodges Y K, Meltesen L, Perryman M B, Horwitz K B, Horwitz L D. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. Genomics. 1998;53:410-2 https://doi.org/10.1006/geno.1998.5442
  30. Boyd D, Jain S K, Crampton J, Barrett K J, Drysdale J. Isolation and characterization of a cDNA clone for human ferritin heavy chain. Proc. Nat. Acad. Sci. 1984;81:4751-5 https://doi.org/10.1073/pnas.81.15.4751
  31. Caskey J H, Jones C, Miller Y E, Seligman P A. Human ferritin gene is assigned to chromosome 19. Proc. Nat. Acad. Sci. 1983;80:482-6 https://doi.org/10.1073/pnas.81.15.4751
  32. Oberle S, Schroder H. Ferritin may mediate SIN-1-induced protection against oxidative stress. Nitric Oxide. 1997, Aug;1(4):308-14 https://doi.org/10.1006/niox.1997.0132
  33. Nakashima K. Liver fructose-1,6-bisphophatase (author's transl). Ta-npakushitsu Kakusan Koso. 1977;22(12):15859
  34. Melloni E, Salamino F, Accorsi A. Degradation of rabbit liver fructo- se 1,6-bisphophatase by lysosomal proteinases. Ital J Biochem. 1974, Nov-Dec;23(6):412-22
  35. Shih DQ, Navas MA, Kuwajima S, Duncan SA, Stoffel M. Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A. 1999, Aug, 31;96(18):10152-7 https://doi.org/10.1073/pnas.96.18.10152
  36. Baudier J, Deloulme J C, Van Dorsselaer A, Black D, Matthes H W D. Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17):identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain. J. Biol. Chem. 1991;266:229-37
  37. Martinez de Arrieta C, Perez Jurado L, Bernal J, Coloma A. Structure, organization, and chromosomal mapping of the human neurogra- ningene (NRGN). 1997;Genomics 41: 243-9 https://doi.org/10.1006/geno.1997.4622
  38. Janowski B A, Grogan M J, Jones S A, Wisely G B, Kliewer S A, Corey E J, Mangelsdorf D J. Structural requirements of ligands for the oxysterol liver X receptors LXR-alpha and LXR-beta. Proc. Nat. Acad. Sci. 1999;96:266-71 https://doi.org/10.1073/pnas.96.1.266
  39. Shinar D M, Endo N, Rutledge S J, Vogel R, Rodan G A, Schmidt A. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. 1994;Gene 147:273-6 https://doi.org/10.1016/0378-1119(94)90080-9
  40. Kohro T, Nakajima T, Wada Y, Sugiyama A, Ishii M, Tsutsumi S, Aburatani H, Imoto I, Inazawa J, Hamakubo T, Kodama T, Emi M. Genomic structure and mapping of human orphan receptor LXR alpha: upregulation of LXRa mRNA during monocyte to macrophage differentiation. J Atheroscler Thromb. 2000;7(3):14551