Journal of Oriental Neuropsychiatry (동의신경정신과학회지)
- Volume 19 Issue 3
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- Pages.101-115
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- 2008
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- 1226-6396(pISSN)
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- 2234-4942(eISSN)
Experimental Study on the Antidepressant Effect of Sam-Jeong-Hwan
삼정환(三精九)의 항우울 효과에 대한 실험적 연구
- Lee, Sang-Taek (College of Korean Medicine, Dongguk University) ;
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Kim, Geun-Woo
(College of Korean Medicine, Dongguk University) ;
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Koo, Byung-Soo
(College of Korean Medicine, Dongguk University)
- Published : 2008.11.30
Abstract
Objective: The purpose of this study was to investigate the protective effects of Sam-Jeong-Hwan(SJH) on the animal model of depression induced immobilization stress. Method: The subject were divided into 4 groups(l. normal 2. saline solution administered during immobilization stress treatment 3. SJH of 100mg/kg administered 4. BKJ of 400mg/kg administered). Immobilization stress was treated for 1 hours on day. During 2 days of immobilization stress treatment, they were executed forced swimming test, passive avoidance test, elevated plus maze test. Corticosterone and ACTH in blood were measured. Results: In forced swimming test, SJH of 400mg/kg group showed decreased immobilization. In passive avoidance test, SJH of 400mg/kg group showed increased learning execution. In EPM test, SJH of 400mg/kg group showed decreased anxiety. In locomotor activity test, SJH groups showed significantly increased locomotor activity. Stress group showed significantly increase in serum level of corticosterone, SJH of 400mg/kg group showed decreased serum level of corticosterone. Stress group showed significantly increase in serum level of ACTH, SJH of 400mg/kg group showed decreased serum level of ACTH. Conclusion: These results suggest that Sam-Jeong-Hwan(SJH) is effective in the treatment of depression.