대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)
- 제21권4호
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- Pages.69-89
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- 2008
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
성유탕가감방(聖愈湯加減方)의 항염증(抗炎症) 및 항산화(抗酸化)
The Experimental Study on Anti-oxidant and Anti-inflammatory Effect of Sungyoutanggagambang(SYTG)
- Kim, Eui-Il (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Yoo, Dong-Youl (Dept. of Oriental Medicine Graduate School, Daejeon University)
- 발행 : 2008.11.29
초록
Purpose: This study was performed to evaluate anti-oxidant activities and anti-inflammatory effects of Sungyoutanggagambang(SYTG). Methods: In the study of anti-oxidant activities. SYTG was investigated by DPPH radical scavenger activity. superoxide dismutase activity and superoxide anion radical scavenger activity. In the study of anti-inflammatory effects. SYTG was investigated using cultured cells and murine models. As for the parameters of inflammation. levels of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were measured in mouse lung fibroblast cells(mLFCs) and RAW264.7 cells. Results: Prior to the experiment. we investigated the security of SYTG by measuring GOT and GPT in serum. 1. SYTG showed high antioxidant activity in a concentration-dependent degree by measured scavenging activity of DPPH free radical, superoxide dismutase and superoxide anion radical. 2. SYTG inhibited IL-1