Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
권호 표지

Serotype Variations of Agglutinogen and Fimbriae in the Korean Isolates of Bordetella pertussis

국내 Bordetella pertussis 분리균주에서 Agglutinogen과 Fimbriae 혈청형 변이 분석

  • Jung, Sang-Oun (Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention) ;
  • Moon, Yu-Mi (Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention) ;
  • Sung, Hwa-Young (Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention) ;
  • Kang, Yeon-Ho (Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention) ;
  • Yu, Jae-Yon (Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention)
  • 정상운 (질병관리본부 국립보건연구원 감염병센터 결핵호흡기세균팀) ;
  • 문유미 (질병관리본부 국립보건연구원 감염병센터 결핵호흡기세균팀) ;
  • 성화영 (질병관리본부 국립보건연구원 감염병센터 결핵호흡기세균팀) ;
  • 강연호 (질병관리본부 국립보건연구원 감염병센터 결핵호흡기세균팀) ;
  • 유재연 (질병관리본부 국립보건연구원 감염병센터 결핵호흡기세균팀)
  • Published : 2008.09.30
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Abstract

Bordetella pertussis is pathogenic bacteria causing pertussis, a infectious respiratory disease for the infants. The incidence rate of pertussis was significantly decreased after introduction of vaccine. However, increased pertussis cases are recently reported in several countries with high vaccine coverage. One of the inferred reasons is genotype or serotype variation between circulating strains and vaccine strains. Therefore, it is required to confirm the variation status of the isolates by genotype or serotype analysis and the possibility of pertussis outbreak in Korea should be estimated. For this, the serotype variations of the isolates from $1999\sim2006$ were investigated in agglutinogen and fimbriae. As the result, the most frequent serotype in the isolated strains was agglutinogen 1 and fimbriae 2 serotypes. Moreover, serotype transition from vaccine serotypes to non-vaccine serotypes was observed. Especially, the transition pattern of agglutinogen serotype was directed to increase a different type (agg 1) from the vaccine type (agg 1,2). However, in case of fimbriae, the same type (fim 2) with vaccine strain was increased. These results were also observed in other countries with increasing incidence of pertussis. For more predictable results to know increasing possibility of pertussis incidence in Korea, the studies on genetic variations of antigenic determinant genes and prevalence of antibody titer in normal population should be performed in the further.

Bordetella pertussis는 유아의 호흡기감염질환인 백일해의 원인균으로 배신도입에 의해 발생률이 크게 낮아졌다. 그러나 최근에 일부 백신접종률이 높은 국가에서 증가된 백일해 발생건수가 보고되고 있으며, 그 추정 원인 중에 하나는 백신주와 유행주 사이의 유전형 흑은 혈청형 변이 이다. 따라서 분리주에 대한 변이 현황을 유전형 혹은 혈청형 분석을 통하여 확인하는 것이 필요하고 국내에서 백일해 발병증가에 대한 가능성을 추정해야 한다. 이에 본 연구에서는 $1999\sim2006$년 사이에 분리된 국내 백일해 분리균주의 변이 양상을 agglutinogen과 fimbriae에 대한 혈청형 조사를 통해 확인하였다. 그 결과 agg 1과 fim 2가 국내 분리주에서 가장 많이 발견되는 혈청형이었고, 두 항원 모두 시대에 따른 혈청형 변이 현상이 확인되었으며, 특히 agglutinogen의 경우는 백신균주(agg 1,2)와는 다른 유형(agg 1)이 증가되는 유형으로 나타났다. 그러나 fimbriae의 경우는 백신균주(fim 2)와 동일한 유형이 증가되어 차이를 나타내었다. 이러한 결과는 백일해 발병증가가 나타나는 국가들에서도 확인되는 현상으로 국내에서의 백일해 발병증가에 대한 보다 정확한 예측을 위해서는 항원결정기 유전자에 대한 변이정도 및 정상인에서의 항체가 분포양상 등에 대한 연구가 필요할 것으로 사료된다.

Keywords

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