Journal of the Korean Ceramic Society (한국세라믹학회지)

The Korean Ceramic Society (한국세라믹학회)
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Fabrication and Characterization of Porous TCP coated Al2O3 Scaffold by Polymeric Sponge Method

  • Sarkar, Swapan Kumar (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Kim, Young-Hee (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Kim, Min-Sung (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Song, Ho-Yeon (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University)
  • Published : 2008.10.31
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Abstract

A porous $Al_2O_3$, scaffold coated with tricalcium phosphate(TCP) was fabricated by replica method using polyurethane(PU) foam as a fugitive material. Successive coatings of $Al_2O_3$ and hydroxyapatite(HAp) were applied via dip coating onto polyurethane foam, which has a slender and well interconnected network. A porous structure was obtained after sequentially burning out the foam and then sintering at $1500^{\circ}C$. The HAp phase was changed to TCP phase at high temperature. The scaffold showed excellent interconnected porosity with pore sizes ranging from $300{\sim}700{\mu}m$ in diameter. The inherent well interconnected structural feature of PU foam remained intact in the fabricated porous scaffold, where the PU foam material was entirely replaced by $Al_2O_3$ and TCP through a consecutive layering process. Thickness of the $Al_2O_3$ base and the TCP coating was about $7{\sim}10{\mu}m$ each. The TCP coating was homogeneously dispersed on the surface of the $Al_2O_3$ scaffold.

Keywords

References

  1. Y. Yan, X. Zhuo, and Y. Hu, "Layered Manufacturing of Tissue Engineering Scaffolds Via Multi-nozzle Deposition," Mater. Lett., 57 2623-28 (2003) https://doi.org/10.1016/S0167-577X(02)01339-3
  2. V. Sikavitsas, G. Bancroft, Mikos, "Formation of Threedimensional Cell/polymer Constructs for Bone Tissue Engineering in a Spinner Flask and a Rotating Wall Vessel Bioreactor," J. Biomed. Mater. Res., 62 136-48 (2002) https://doi.org/10.1002/jbm.10150
  3. G.T. Kose and H. Kenar, "Macroporous Poly(3-hydroxybutyrate- co-3-hydroxyvalerate) Matrices for Bone Tissue Engineering," Biomaterials, 24 1949-58 (2003) https://doi.org/10.1016/S0142-9612(02)00613-0
  4. J.P. Vacanti, C.A. Vacanti, R. Langer, "Principles of Tissue Engineering," p. 1, Academic Press, San Diego, 1997
  5. S.L. Ishaug, G.M. Crane, M.J. Miller, A.W. Yasko, M.J. Yazemski, and A.G. Mikos, "Bone Formation by Threedimensional Stromal Osteoblast Culture in Biodegradable Polymer Scaffolds," J. Biomed. Mater. Res., 36 17-28 (1997) https://doi.org/10.1002/(SICI)1097-4636(199707)36:1<17::AID-JBM3>3.0.CO;2-O
  6. H. Yoshimoto, Y.M. Shin, H. Terai, and J.P. Vacanti, "A Biodegradable Nanofiber Scaffold by Electrospinning and its Potential for Bone Tissue Engineering," Biomaterials, 24 2077-82 (2003) https://doi.org/10.1016/S0142-9612(02)00635-X
  7. Y. Hu, D.W. Grainger, S.R. Winn, and J.O. Hollinger, "Fabrication of Poly(-hydroxy acid) foam Scaffolds Using Multiple Solvent Systems," J. Biomed. Mater. Res., 59 563-72 (2001) https://doi.org/10.1002/jbm.1269
  8. T. Nezu, F.M. Winnik, "Interaction of Water-soluble Collagen with Poly(acrylic acid)," Biomaterials, 21 415-19 (2000) https://doi.org/10.1016/S0142-9612(99)00204-5
  9. L. Huang, K. Nagapaudi, R.P. Apkarian, and E.L. Chaikof, "Engineered Collagen-PEO Nanofibers and Fabrics," J. Biomater. Sci. Polym. Ed., 12 979-93 (2001) https://doi.org/10.1163/156856201753252516
  10. A.S. Goldstein, G. Zhu, G.E. Morris, R.K. Meslenyi, and A.G. Mikos, "Effect of Osteoblastic Culture Conditions on the Structure of Poly(DL-Lactic-co-Glycolic Acid) Foam Scaffolds," Tissue Eng., 5 421-33 (1999) https://doi.org/10.1089/ten.1999.5.421
  11. K. D. Groot, "Bioceramics Consisting of Calcium Phosphate Salts," Biomaterials, 1 47-50 (1980) https://doi.org/10.1016/0142-9612(80)90059-9
  12. M. Jarcho, "Calcium Phosphate as a Hard Tissue Prosthetics," Clin. Orthop. Rel. Res., 157 259-78 (1981)
  13. C. J. Damien and J. R. Parsons, "Bone Graft and Bone Graft Substitutes: A Review of Current Technology and Applications," J. Appl. Biomaterials, 2 187-208 (1990)
  14. H. W. Kim, S. Y. Lee, C. J. Bae, Y. J. Noh, H. E. Kim, H. M. Kim, and J. S. Ko, "Porous $ZrO_2$ Bone Scaffold Coated with Hydroxyapatite with Fluorapatite Intermediate Layer," Biomaterials, 24 3277-82 (2003) https://doi.org/10.1016/S0142-9612(03)00162-5
  15. H.W. Kim, J.C. Knowles, and H.E. Kim, "Hydroxyapatite/ poly($\varepsilon$-caprolactone) Composite Coatings on Hydroxyapatite Porous Bone Scaffold for Drug Delivery," Biomaterials, 25 1279-87 (2004) https://doi.org/10.1016/j.biomaterials.2003.07.003
  16. S. F. Hulbert, F. A. Young, R. S. Mathews, J. J. Klawitter, C. D. Talbert, and F. H. Stelling, "Potential of Ceramic Materials as Permanently Implantable Skeletal Prostheses," J. Biomed Mater. Res., 4 433-56 (1970) https://doi.org/10.1002/jbm.820040309
  17. P. Griss and E. Werner, "Mechanical Properties of Biomaterials," p. 217, Wiley, London, 1980
  18. D. J. Green., "An Introduction to the Mechanical Properties of Ceramics," Cambridge University Press; Cambridge, 1998
  19. D. Munz and T. Fett, "Ceramics: Mechanical Properties, Failure Behaviour, Materials Selection, 1st ed," Springer, Berlin, Heidelberg, New York, 1999
  20. H. Fischer, C. Niedhart, N. Kaltenborn, A. Prange, R. Marx, F. U. Niethard, and R. Telle, "Bioactivation of Inert Alumina Ceramics by Hydroxylation," Biomaterials, 26 6151-57 (2005) https://doi.org/10.1016/j.biomaterials.2005.04.038
  21. E.A. Moreira, M.D.M. Innocentini, and J.R. Coury, "Permeability of Ceramic Foams to Compressible and Incompressible Flow," J. Euro. Ceram. Soc., 24 3209-18 (2004) https://doi.org/10.1016/j.jeurceramsoc.2003.11.014
  22. J.K. Han, H.Y. Song, F. Saito, B.T. Lee, "Synthesis of High Purity Nano-sized Hydroxyapatite Powder by Microwavehydrothermal Method," Mater. Chem. Phy., 99 235-39 (2006) https://doi.org/10.1016/j.matchemphys.2005.10.017
  23. L. Cerroni, R. Filocamo, M. Fabbri, C. Piconi, S. Caropreso, S.G. Condo, "Growth of Osteoblast-like Cells on Porous Hydroxyapatite Ceramics: an in Vitro Study," Biomolecular Engineering, 19 119-24 (2002) https://doi.org/10.1016/S1389-0344(02)00027-8
  24. W.A. Kaysser, M.Sprissler, C.A. Handwerker, J.E. Blendelll, "Effect of a Liquid Phase on the Morphology of Grain Growth in Alumina," J. Am. Ceram. Soc., 70 [5] 339-43 (1987) https://doi.org/10.1111/j.1151-2916.1987.tb05005.x

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