대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제28권3호
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- Pages.510-518
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- 2007
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- 1226-9174(pISSN)
자음양영탕이 Streptozotocin(STZ)로 유발된 생쥐의 고혈당에 미치는 영향(影響)
Effect of Jaeumyangyung-tang on the Hyperglycemic Mice Induced with Streptozotocin
- Lee, Hyung-Ho (Department of internal, College of Oriental Medicine, Dong-shin University) ;
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Lee, Young-Soo
(Department of internal, College of Oriental Medicine, Dong-shin University)
- 발행 : 2007.09.30
초록
Objectives : The aim of this study was to investigate the effect of Jaeumyangyung-tang(滋陰養榮場(JY), JA-0.65g/kg;JB-1.3g/kg) on hyperglycemic mice induced with streptozotocin(STZ). Methods : The experiment operated for 6 weeks. The rats were divided into 3 groups : diabetic group(control group), diabetic group treated with JA(0.65g/kg) for 6 weeks, and diabetic group treated with Jb(1.3g/kg) for 6 weeks. Results : In the STZ-induced diabetic group, blood glucose levels significantly increased as well as the loss of body weight. The levels of serum glucose decreased significantly (p<0.05 or p<0.01) in the JA and JB groups compared with the control. According to a tolerance test, intraperitoneal glucose was ameliorated in the JA and JB groups. The blood urea nitrogen (BUN) and creatinine levels slightly decreased. Histologic analyses of the pancreases revealed that the