대한한의학방제학회지 (Herbal Formula Science)
- 제15권1호
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- Pages.199-211
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- 2007
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
소풍도적산의 iNOS 발현과 NO 생성 억제가 아토피 피부염에 미치는 영향
Sopungdojeok-San Inhibits Atopy-liked Dermal Inflammation through Regulation of iNOS mRNA Expresssion & NO production
- Ahn, Sang-Hyun (Dept. of Anatomy, Oriental medicine college, Dongguk University) ;
- Kim, Jin-Taek (Dept. of Anatomy, Oriental medicine college, Dongguk University)
- 발행 : 2007.06.30
초록
Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricated with pathogenesis of inflammation diseases as atopy dermatitis. The present study was designed in order to determine whether Sopungdojeok-san could inhibit atopy dermatitis through modulation of iNOS mRNA expression and NO production, We found that iNOS mRNA expression and NO production in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Sopungdojeok-san extract treatment (0.4 - 1.0 mg/ml). The distribution of iNOS positive reacted cell in atopy dermatitis elicited skin of mice were remarkably decreased by Sopungdojeok-san administration (2.5 ml/kg/day). The SOD ability of Sopungdojeok-san were dose-dependantly increased from 0.6 mg/ ml than butylated hydroxyanisole. These data likely indicate that Sopungdojeok-san may act as inflammatory regulator for atopy dermatitis may be possible to develop useful agent for chemopreventation of NO-intricate inflammatory diseases.