The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 28 Issue 2
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- Pages.304-320
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- 2007
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- 1226-9174(pISSN)
Effect of Astragalus Membranaceus Extract against Improvement of Myelosuppression and Quality of Life in 5-Fluorouracil Treated Mice
황기 추출물이 5-Fluorouracil을 투여한 생쥐의 골수억제 및 삶의 질에 미치는 영향
- Kwon, Chang-Hyun (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Yoo, Hwa-Seung (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Bang, Sun-Hwi (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Lee, Young-Min (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Lee, Yeon-Weol (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Son, Chang-Gue (Department of East-West Cancer Center, Oriental Hospital of Daejeon University) ;
- Cho, Chong-Kwan (Department of East-West Cancer Center, Oriental Hospital of Daejeon University)
- 권창현 (대전대학교 둔산한방병원 동서암센터) ;
- 유화승 (대전대학교 둔산한방병원 동서암센터) ;
- 방선휘 (대전대학교 둔산한방병원 동서암센터) ;
- 이영민 (대전대학교 둔산한방병원 동서암센터) ;
- 이연월 (대전대학교 둔산한방병원 동서암센터) ;
- 손창규 (대전대학교 둔산한방병원 동서암센터) ;
- 조종관 (대전대학교 둔산한방병원 동서암센터)
- Published : 2007.06.30
Abstract
Objective : To evaluate the effect of Astragalus Membranaceus Extrac (AME) on myelosuppression, activity and immune modulation in 5-fluorouracil (5-FU) treated mice. Method : We carried out complete blood count, histological analysis of bone marrow, and cell colony forming assay for hematopoietic progenitor to evaluate the effect of AME on myelosuppression and conducted swimming test, survival rate, nitric oxide (NO) assay, 51Cr release assay in natural killer cell, mRNA expression of
목적 : 황기추출물이 생쥐의 5-FU로 유발된 골수억제와 삶의 질 저하의 개선에 미치는 효과를 연구하고자 한다. 방법 : 골수억제에 미치는 영향이 평가를 위해 Complete Blood Count, Histological Analysis of BM, Cell Colony Forming Assay for Hematopoietic Progenitor를 시행하고, 삶의 질에 미치는 영향을 평가하기 위해 Swimming Test, Survival Rate, Nitric Oxide (NO) Assay,
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